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EGR1 and EGR2 positively regulate plant ABA signaling by modulating the phosphorylation of SnRK2.2

文献类型： 外文期刊

作者： Li, Chuanling 1 ; Li, Xuetong 1 ; Deng, Zhiping 3 ; Song, Yuning 1 ; Liu, Xinye 1 ; Tang, Xiaohan Alex 4 ; Li, Ziye 1 ; Zhang, Ya 1 ; Zhang, Baowen 1 ; Tang, Wenqiang 1 ; Shang, Jian-Xiu 1 ; Sun, Yu 1 ;

作者机构： 1.Hebei Normal Univ, Minist Educ, Hebei Key Lab Mol & Cellular Biol, Coll Life Sci,Hebei Res Ctr Basic Discipline Cell, Shijiazhuang 050024, Peoples R China

2.Chinese Acad Trop Agr Sci, South Subtrop Crops Res Inst, Key Lab Trop Fruit Biol, Minist Agr & Rural Affairs, Zhanjiang 524091, Peoples R China

3.Zhejiang Acad Agr Sci, Inst Virol & Biotechnol, Hangzhou 310021, Peoples R China

4.Hong Kong Univ Sci & Technol, Div Life Sci, Kowloon, Hong Kong, Peoples R China

关键词： abscisic acid; Arabidopsis thaliana; EGR1; EGR2; protein phosphorylation; serine 31; SnRK2.2

期刊名称：NEW PHYTOLOGIST （ 影响因子：9.4； 五年影响因子：10.5 ）

ISSN： 0028-646X

年卷期： 2024 年 241 卷 4 期

页码：

收录情况： SCI

摘要： center dot During abscisic acid (ABA) signaling, reversible phosphorylation controls the activity and accumulation of class III SNF1-RELATED PROTEIN KINASE 2s (SnRK2s). While protein phosphatases that negatively regulate SnRK2s have been identified, those that positively regulate ABA signaling through SnRK2s are less understood.center dot In this study, Arabidopsis thaliana mutants of Clade E Growth-Regulating 1 and 2 (EGR1/2), which belong to the protein phosphatase 2C family, exhibited reduced ABA sensitivity in terms of seed germination, cotyledon greening, and ABI5 accumulation. Conversely, overexpression increased these ABA-induced responses. Transcriptomic data revealed that most ABA-regulated genes in egr1 egr2 plants were expressed at reduced levels compared with those in Col-0 after ABA treatment.center dot Abscisic acid up-regulated EGR1/2, which interact directly with SnRK2.2 through its C-terminal domain I. Genetic analysis demonstrated that EGR1/2 function through SnRK2.2 during ABA response. Furthermore, SnRK2.2 de-phosphorylation by EGR1/2 was identified at serine 31 within the ATP-binding pocket. A phospho-mimic mutation confirmed that phosphorylation at serine 31 inhibited SnRK2.2 activity and reduced ABA responsiveness in plants.center dot Our findings highlight the positive role of EGR1/2 in regulating ABA signaling, they reveal a new mechanism for modulating SnRK2.2 activity, and provide novel insight into how plants fine-tune their responses to ABA.

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