Elucidating the role of DNA methylation in low-salinity adaptation of the swimming crab Portunus trituberculatus
文献类型： 外文期刊
作者： Guo, Junyang 1 ; Lv, Jianjian 1 ; Sun, Dongfang 1 ; Liu, Ping 1 ; Gao, Baoquan 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Natl Key Lab Mariculture Biobreeding & Sustainable, Qingdao 266071, Peoples R China
2.Jiangsu Ocean Univ, Coll Marine Sci & Fisheries, Lianyungang 222005, Jiangsu, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Funct Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266071, Peoples R China
关键词： Portunus trituberculatus; DNA methylation; Gill; Low salinity; Molecular mechanisms
期刊名称：AQUACULTURE （ 影响因子：3.9； 五年影响因子：4.4 ）
ISSN： 0044-8486
年卷期： 2025 年 595 卷
页码：
收录情况： SCI
摘要： The swimming crab Portunus trituberculatus holds significant economic value in the aquaculture industry in China. Salinity is an important environmental factor that affects its growth and susceptibility to diseases. DNA methylation, a well-studied epigenetic mechanism, plays a pivotal role in the stress response of organisms. Herein we performed whole-genome bisulfite sequencing (WGBS) to assess changes in DNA methylation patterns in P. trituberculatus gill tissues before and after exposure to low-salinity stress. Overall, 33,712 differentially methylated regions (DMRs) were screened and 3546 functional genes were identified, many of which were notably enriched in pathways related to, for example, proteolysis and amino acid metabolism. By integrating WGBS and previous RNA-seq data, we identified 187 overlapping genes between differentially expressed genes and differentially methylated genes. Our findings reveal molecular mechanisms via which DNA methylation participates in low-salinity adaptation by regulating gene expression. Moreover, our data provide preliminary evidence of the substantial role of DNA methylation in facilitating salinity adaptation in P. trituberculatus and contribute to a systematic understanding of the mechanisms underpinning low-salinity adaptation in this species.
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