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Fatty acid synthase inhibitors from the hulls of Nephelium lappaceum L.

文献类型： 外文期刊

作者： Zhao, You-Xing 1 ; Liang, Wen-Juan 3 ; Fan, Hui-Jin 2 ; Ma, Qing-Yun 1 ; Tian, Wei-Xi 2 ; Dai, Hao-Fu 1 ; Jiang, He-Zh 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China

2.Chinese Acad Sci, Coll Life Sci, Grad Univ, Beijing 100049, Peoples R China

3.Chinese Acad Sci Kunming, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

4.Anhui Univ, Sch Life Sci, Hefei 230039, Peoples R China

期刊名称：CARBOHYDRATE RESEARCH （ 影响因子：2.104； 五年影响因子：2.192 ）

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收录情况： SCI

摘要： Natural products inhibiting fatty acid synthase (FAS) are appearing as potential therapeutic agents to treat cancer and obesity. The bioassay-guided chemical investigation of the hulls of Nephelium lappaceum L. resulted in the isolation of ten compounds (1-10) mainly including flavonoids and oleane-type triterpene oligoglycosides, in which all of the compounds were isolated from this plant for the first time. Additionally, compounds 8 and 9 were new hederagenin derivatives and were elucidated as hederagenin 3-O-(2,3-di-O-acetyl- α-L-arabinofuranosyl)-(1→3)-[α-L-rhamnopyranosyl(1→2)] -β-L-arabinopyranoside and hederagenin 3-O-(3-O-acetyl-α-L- arabinofuranosyl)-(1→3)-[α-L-rhamnopyranosyl-(1→2)] -β-L-arabinopyranoside, respectively. All these isolates were evaluated for inhibitory activities of FAS, which showed these isolates had inhibitory activity against FAS with IC_(50) values ranging from 6.69 to 204.40 μM, comparable to the known FAS inhibitor EGCG (IC_(50) = 51.97 μM). The study indicates that the hulls of Nephelium lappaceum L. could be considered as potential sources of promising FAS inhibitors and the oleane-type triterpene oligoglycosides could be considered as another type of natural FAS inhibitors.

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