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Chmp1A acts as a tumor suppressor gene that inhibits proliferation of renal cell carcinoma

文献类型： 外文期刊

作者： You, Zhenqiang 1 ; Xin, Yanfei 1 ; Liu, Yan; Sun, Junying; Zhou, Guoliang 1 ; Gao, Haiyan 1 ; Xu, Pansheng 1 ; Chen 1 ;

作者机构： 1.Zhejiang Acad Med Sci, State Key Lab Safety Evaluat New Drugs, Hangzhou 310013, Zhejiang, Peoples R China

2.Zhejiang Acad Med Sci, State Key Lab Safety Evaluat New Drugs

关键词： Chromatin modifying protein 1A (Chmp1A);Renal cell carcinoma (RCC);Tumor suppressor

期刊名称：CANCER LETTERS （ 影响因子：8.679； 五年影响因子：8.64 ）

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收录情况： SCI

摘要： Renal cell carcinoma (RCC) is a highly malignant and often fatal disease of the kidney. Chmp1A is a member of the Endosomal Sorting Complex Required for Transport (ESCRT-III) family, and plays a role in the cytoplasm in sorting proteins to the multivesicular body (MVB). Chmp1A functions as a tumor suppressor gene and has been reported in pancreatic tumor cells. Here, we examined the expression level of Chmp1A in human RCC tissues and renal tumor cells by real-time quantitative RT-PCR and western blot. We found that the expression level of Chmp1A is significantly lower in RCC tissues and renal tumor cells compared with adjacent non-tumorous tissues and normal renal cells. Additionally, inhibition of Chmp1A expression by shRNA induced tumor formation in normal renal cells. However, inhibition of Chmp1A did not significantly affect tumor cell proliferation . in vitro and tumor progression . in vivo. Interestingly, overexpression of Chmp1A using a eukaryotic plasmid inhibited the proliferation of renal tumor cells . in vitro and the growth of renal tumor . in vivo. Thus, our results demonstrate that Chmp1A functions as a tumor suppressor gene in renal cells and may be a useful target for treatment of RCC.

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