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Fatty acid synthase inhibitors isolated from Punica granatum L.

文献类型： 外文期刊

作者： Jiang, He-Zhong 2 ; Ma, Qing-Yun 2 ; Fan, Hui-Jin 1 ; Liang, Wen-Juan 2 ; Huang, Sheng-Zhuo 2 ; Dai, Hao-Fu 2 ; Wang, 1 ;

作者机构： 1.Chinese Acad Sci, Grad Univ, Coll Life Sci, Beijing 100049, Peoples R China

2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China

3.SW Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Peoples R China

关键词： Fatty acid synthase (FAS);Flavogallonic acid;Punica granatum;Punicaone

期刊名称：JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY （ 影响因子：1.838； 五年影响因子：1.9 ）

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收录情况： SCI

摘要： The aim of this work is the isolation of fatty acid synthase (FAS) inhibitors from the ethyl acetate extracts of fruit peels of Punica granatum L. Bioassay-guided chemical investigation of the fruit peels resulted in the isolation of seventeen compounds mainly including triterpenoids and phenolic compounds, from which one new oleanane-type triterpene (punicaone) along with fourteen known compounds were isolated for the first time from this plant. Seven isolates were evaluated for inhibitory activities of FAS and two compounds showed to be active. Particularly, flavogallonic acid exhibited strong FAS inhibitory activity with IC _(50) value of 10.3 μmol L _(-1).

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[1]Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana. Quan, Xiao Fang,Tian, Wei Xi,Ma, Xiao Feng,Jiang, He Zhong,Hu, Jiang Miao,Wang, Peng Cheng,Huang, Sheng Zhuo,Cheng, Zhong Quan,Liang, Wen Juan,Zhou, Jun,Zhao, You Xing,Zhao, You Xing. 2010

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