Isolation of a new meroterpene and inhibitors of nitric oxide production from Psoralea corylifolia fruits guided by TLC bioautography
文献类型： 外文期刊
作者： Xiao, Guodong 1 ; Li, Xiangkun 1 ; Wu, Tao 1 ; Cheng, Zhihong 2 ; Tang, Qingjiu 3 ; Zhang, Tong 1 ;
作者机构： 1.Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, Shanghai Key Lab Compound Chinese Med, Key Lab Standardizat Chinese Med,Minist Educ, Shanghai 201203, Peoples R China
2.Fudan Univ, Dept Pharmacognosy, Shanghai 201203, Peoples R China
3.Shanghai Acad Agr Sci, Shanghai Edible Fungi Inst, Shanghai 201106, Peoples R China
关键词： Meroterpene;Psoralea corylifolia;TLC bioautography;NO production
期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）
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收录情况： SCI
摘要： A new meroterpene, psoracorylifol F (1), was isolated from Psoralea corylifolia fruits, along with two known meroterpenes (2 and 3), guided by TLC bioautography against O-2 center dot(-) radicals. The structure of 1 was elucidated by means of NMR, HRESIMS, and X-ray crystallographic analysis. All the three metroterpenes possessed potential inhibitory activity against LPS-induced NO production in RAW 264.7 cells with IC50 values ranging from 7.71 to 27.63 mu M
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