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Effect of epimedium polysaccharide-propolis flavone immunopotentiator on immunosuppression induced by cyclophosphamide in chickens

文献类型： 外文期刊

作者： Fan, Yunpeng 1 ; Lu, Yu 3 ; Wang, Deyun 1 ; Liu, Jiaguo 1 ; Song, Xiaoping 2 ; Zhang, Weimin 2 ; Zhao, Xiaojuan 1 ; Luong 1 ;

作者机构： 1.Nanjing Agr Univ, Coll Vet Med, Inst Tradit Chinese Vet Med, Nanjing 210095, Peoples R China

2.Northwest A&F Univ, Coll Vet Med, Yangling 712100, Shaanxi, Peoples R China

3.Jiangsu Acad Agr Sci, Natl Res Ctr Vet Biol Engn & Technol, Nanjing 210014, Peoples R China

关键词： Cytokine;EPI;Immunoglobulin;Immunosuppression;Lymphocyte proliferation;Serum antibody titer

期刊名称：CELLULAR IMMUNOLOGY （ 影响因子：4.868； 五年影响因子：4.706 ）

ISSN：

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收录情况： SCI

摘要： Two hundred and fifty 11-day-old chickens were randomly assigned into 5 groups and except normal control group injected with cyclophosphamide once a day for 3 successive days. At day-14-old, all chickens were vaccinated with Newcastle disease vaccine. At the same time of the first vaccination, the chickens in three experimental groups were injected respectively with epimedium polysaccharide-propolis flavone immunopotentiator (EPI) at three dosages, once a day for 3 successive days. On days 7, 14, 21 and 28 after the first vaccination, the serum antibody titer and IgG, IgM, IFN-γ and IL-6 concentrations, peripheral lymphocyte proliferation, including immune organ index on day 28, were measured. The results demonstrated that EPI at high and medium doses could significantly enhance antibody titer and IgG, IgM, IFN-γ and IL-6 concentrations, promote lymphocyte proliferation and enlarge immune organ index as compared with model control group. This indicated that EPI could effectively resist the immunosuppression.

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