文献类型： 外文期刊
作者： Zhou, Xuefeng 1 ; Lin, Xiuping 1 ; Ma, Wanlei 1 ; Fang, Wei; Chen, Zhefang 1 ; Yang, Bin 1 ; Liu, Yonghong 2 ;
作者机构： 1.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China
2.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources
关键词： Pestalotiopsis vaccinii;Pestalamine A;Cytotoxicity
期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.679； 五年影响因子：1.861 ）
ISSN：
年卷期：
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收录情况： SCI
摘要： A new aromatic amine named pestalamine A (1), as well as a known diketopiperazine (2) and four known phenol or aromatic amine derivatives (3-6) were isolated from mangrove-derived endophytic fungus Pestalotiopsis vaccinii. The structure of pestalamine A (1) was determined by spectroscopic methods, especially 2D NMR analyses. Pestalamine A (1) showed moderate cytotoxicities against MCF-7, HeLa, and HepG2 human cancer cell lines with IC50 values of 40.3, 22.0, and 32.8 mu M, respectively.
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