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Spatial Learning and Memory Impairment and Pathological Change in Rats Induced by Acute Exposure to Microcystin-LR

文献类型： 外文期刊

作者： Li, Guangyu 1 ; Yan, Wei 2 ; Cai, Fei 3 ; Li, Cairong 3 ; Chen, Nan 1 ; Wang, Jianghua 1 ;

作者机构： 1.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China

2.Hubei Acad Agr Sci, Inst Agr Qual Stand & Testing Technol, Wuhan 430064, Peoples R China

3.Xianning Univ, Dept Pharmacol, Coll Med, Xianning 437100, Peoples R China

关键词： microcystin-LR;neurotoxicity;oxidative stress;rat

期刊名称：ENVIRONMENTAL TOXICOLOGY （ 影响因子：4.119； 五年影响因子：3.404 ）

ISSN：

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收录情况： SCI

摘要： Microcystin-LR (MCLR) is a commonly encountered blue-green algal hepatotoxin and a known inhibitor of cellular protein phosphatase. However, little is known about its neurotoxicity. By using Morris water maze, histopathological and biochemical analysis, we investigated MCLR-induced neurotoxicity on the hippocampus of rat brain. After rats were intrahippocampally injected with MCLR (1 and 10 μg/L), their learning and memory function was greatly impaired, suggesting the neurotoxic potential of MCLR. Meanwhile, obvious histological and ultrastructural injuries and serious oxidative damage were also observed in the hippocampus. These results suggested that oxidative stress might be involved in the MCLR-induced pathological damage in hippocampus, subsequently leading to the spatial learning and memory deficit of rat. Taken together, our results highlighted the MCLR-induced neurotoxicity in the rat, as well as the importance of oxidative stress and pathological impairment in this procedure. # 2012 Wiley Periodicals, Inc. Environ Toxicol 29: 261-268, 2014.

  • 相关文献

[1]Microcystin-LR induces changes in the GABA neurotransmitter system of zebrafish. Yan, Wei,Li, Li,Li, Guangyu,Zhao, Sujuan.

[2]Global effects of subchronic treatment of microcystin-LR on rat splenetic protein levels. Li, Guangyu,Qiao, Qin,He, Yan,Zhang, Xuezhen,Yan, Wei,Chen, Jun,Cai, Fei. 2012

[3]Microcystin-LR inhibited hippocampal long-term potential via regulation of the glycogen synthase kinase-3 beta pathway. Wang, Jianghua,Zhou, Qiong,Lin, Fankai,Cai, Fei,Yan, Wei,Xie, Liqiang. 2013

[4]A Proteomic Analysis of MCLR-induced Neurotoxicity: Implications for Alzheimer's Disease. Li, Guangyu,Wang, Jianghua,Cai, Fei,Li, Cairong,Yan, Wei. 2012

[5]Sedative effects of Arachis hypogaea L. stem and leaf extracts on sleep-deprived rats. Zu, Xiaoyan,Xiong, Guangquan,Liao, Tao,Qiao, Yu,Geng, Shengrong,Li, Xin,Zhang, Zhenya,Li, Yiting. 2013

[6]mrskn7, a putative response regulator gene of Monascus ruber M7, is involved in oxidative stress response, development, and mycotoxin production. Shao, Yanchun,Chen, Fusheng,Yang, Sha,Zhang, Zhouwei,Zhou, Youxiang.

[7]Physiological Effects and Fluorescence Labeling of Magnetic Iron Oxide Nanoparticles on Citrus (Citrus reticulata) Seedlings. Li, Junli,Hu, Jing,Xiao, Lian,Gan, Qiuliang,Li, Junli,Wang, Yunqiang. 2017

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