Cytotoxic and antiviral nitrobenzoyl sesquiterpenoids from the marine-derived fungus Aspergillus ochraceus Jcma1F17
文献类型： 外文期刊
作者： Fang, Wei 1 ; Lin, Xiuping 2 ; Zhou, Xuefeng 2 ; Wan, Junting 1 ; Lu, Xin 1 ; Yang, Bin 2 ; Ai, Wen 2 ; Lin, Ji 2 ; Zhang, T 1 ;
作者机构： 1.Hubei Acad Agr Sci, Ctr Biopesticide Engn Res, Wuhan 430064, Peoples R China
2.Chinese Acad Sci, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol, South China Sea Inst Oceanol,CAS Key Lab Trop Mar, Guangzhou 510301, Guangdong, Peoples R China
3.Chinese Acad Sci, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marin
关键词： Cytotoxic;sesquiterpenoids;Aspergillus
期刊名称：MEDCHEMCOMM （ 影响因子：3.597； 五年影响因子：3.271 ）
ISSN：
年卷期：
页码：
收录情况： SCI
摘要： Nitrobenzoyl sesquiterpenoids are rare in natural sources, and fungi Aspergillus species are the only sources of them. A new nitrobenzoyl sesquiterpenoid, 6b,9a-dihydroxy-14-p-nitrobenzoylcinnamolide (1), and a known analogue, insulicolide A (2), were isolated from extracts of the culture of marine-derived fungus Aspergillus ochraceus Jcma1F17, which was identified by morphological and ITS phylogenetic analyses. The structures were determined by NMR, MS, CD, and optical rotation analyses. Both nitrobenzoyl sesquiterpenoids displayed significant cytotoxicities against 10 cancer cell lines, and the new one (1) also showed antiviral activities against H3N2 and EV71. This is the first time that nitrobenzoyl sesquiterpenoids from A. ochraceus have been reported.
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