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Two Androstane Derivatives from the Cultures of Fungus Marasmiellus ramealis (Bull.) Singer

文献类型： 外文期刊

作者： Yang, Ning-Ning 1 ; Ma, Qing-Yun 1 ; Huang, Sheng-Zhuo 1 ; Dai, Hao-Fu 1 ; Guo, Zhi-Kai 1 ; Yu, Zhi-Fang 2 ; Zhao, You 1 ;

作者机构： 1.CATAS, Inst Trop Biosci & Biotechnol, Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Haikou 571101, Peoples R China

2.Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China

关键词： Marasmiellus ramealis (Bull.) Singer;Fermentation;Androstane derivative;AChE inhibitory activity

期刊名称：BULLETIN OF THE KOREAN CHEMICAL SOCIETY （ 影响因子：0.969； 五年影响因子：0.691 ）

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收录情况： SCI

摘要： A new androstane derivative, 4β-memyl-15-oxa-14β-androstane-7-ene-4α-carboxylic acid (1) and a known one 4βmethyl-15-oxa-14β-androstane-7-ene-4α-hydroxyl (2) were isolated from the EtOAc extract of the cultures of the fungus Marasmiellus ramealis (Bull.) Singer. Their structures were elucidated on the basis of 1D and 2D NMR as well as MS spectroscopic data analysis. The inhibitory activity of two isolates against acetylcholinesterase (AChE) revealed that compound 1 exhibited definitely inhibitory activity.

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