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Lanostanoids with acetylcholinesterase inhibitory activity from the mushroom Haddowia longipes

文献类型： 外文期刊

作者： Zhang, Shuang-Shuang 1 ; Ma, Qing-Yun 1 ; Huang, Sheng-Zhuo 1 ; Dai, Hao-Fu 1 ; Guo, Zhi-Kai 1 ; Yu, Zhi-Fang 3 ; Zhao 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China

2.Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China

3.Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Jiangsu, P

关键词： Haddowia longipes;Lanostanoids;AChE inhibition

期刊名称：PHYTOCHEMISTRY （ 影响因子：4.072； 五年影响因子：4.132 ）

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收录情况： SCI

摘要： Nine lanostanoids, together with nine known ones, were isolated from the ethyl acetate extract of the fruiting bodies of the mushroom Haddowia longipes. Their structures were elucidated as 11-oxo-ganoderiol D, lanosta-8-en-7,11-dioxo-3 beta-acetyloxy-24,25,26-trihydroxy, lanosta-8-en-7-oxo-3 beta-acetyloxy-11 beta,24,25,26-tetrahydroxy, lanosta-7,9(11)-dien-3 beta-acetyloxy-24,25,26-trihydroxy, lanosta-7,9(11)-dien-3 beta-acetyloxy-24,26-dihydroxy-25-methoxy, 11-oxo-lucidadiol, 11 beta-hydroxy-lucidadiol, lucidone H and lanosta-7,9(11),24E-trien-3 beta-acetyloxy-26,27-dihydroxy by analysing their 1D/2D NMR and MS spectra. In addition, bioassays of inhibitory activity against acetylcholinesterase (AChE) of all compounds showed that thirteen compounds possessed inhibitory activity against AChE with the percentage inhibition ranging from 10.3% to 42.1% when tested at 100 mu M. (C) 2014 Elsevier Ltd. All rights reserved.

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