您好，欢迎访问黑龙江省农业科学院 机构知识库！
黑龙江省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Immune responses of porcine airway epithelial cells to poly(I:C), a synthetic analogue of viral double-stranded RNA

文献类型： 外文期刊

作者： Yang, Xiu-qin 1 ; Wang, Liang 2 ; Li, Hai-tao 1 ; Liu, Di 1 ;

作者机构： 1.Northeast Agr Univ, Coll Anim Sci & Technol, Harbin, Peoples R China

2.Heilongjiang Acad Agr Sci, Harbin, Peoples R China

关键词： Swine;airway epithelial cells;immune responses;digital gene expression;poly(I:C)

期刊名称：CANADIAN JOURNAL OF ANIMAL SCIENCE （ 影响因子：1.015； 五年影响因子：1.094 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Swine respiratory disease (SRD) is one of the most economically important diseases affecting the pig industry. The main infectious agents that cause SRD are viruses, but the molecular pathogenesis of viral SRD has not been extensively studied. Here, using digital gene expression tag profiling, the global transcriptional responses to poly(I:C), a synthetic analogue of viral double-stranded RNA, was analyzed in porcine airway epithelial cells (PAECs). The profiling analysis revealed numerous differentially expressed genes (DEGs), including unknown sequences in the porcine nucleotide databases. Gene ontology enrichment analysis showed that DEGs were mainly enriched in response to stress (GO: 0006950), of which, defense response is one sub-process. Poly(I:C) challenge induced a general inflammation response as indicated by marked upregulation of a variety of pathogen recognition receptors, interferon-stimulated genes, proinflammatory cytokines, and chemokines, together with the significant downregulation of anti-inflammatory molecules. Furthermore, the antiapoptotic pathway was triggered, as demonstrated by the significant suppression of molecules involved in the induction of apoptosis, together with the significant stimulation of putative inhibitor of apoptosis. The results indicate that PAECs initiated defense against poly(I: C) challenge through the inflammation responses, whereas poly(I:C) can utilize antiapoptotic pathway to evade host defense.

  • 相关文献

[1]Identification of differentially expressed genes in sunflower (Helianthus annuus) leaves and roots under drought stress by RNA sequencing. Liang, Chunbo,Huang, Xutang,Liang, Chunbo,Wang, Wenjun,Wang, Jing,Ma, Jun,Li, Cen,Zhou, Fei,Zhang, Shuquan,Yu, Ying,Zhang, Liguo,Huang, Xutang,Li, Weizhong. 2017

[2]Transcriptome profiling and digital gene expression by deep sequencing in early somatic embryogenesis of endangered medicinal Eleutherococcus senticosus Maxim.. Tao, Lei,Zhao, Yue,Wu, Ying,Wang, Qiuyu,You, Xiangling,Yuan, Hongmei,Zhao, Lijuan,Guo, Wendong.

[3]Identification of differentially expressed genes in flax (Linum usitatissimum L.) under saline-alkaline stress by digital gene expression. Yu, Ying,Yuan, Hongmei,Guan, Fengzhi,Yu, Ying,Huang, Wengong,Wu, Guangwen,Yuan, Hongmei,Song, Xixia,Kang, Qinghua,Zhao, Dongsheng,Jiang, Weidong,Liu, Yan,Wu, Jianzhong,Cheng, Lili,Yao, Yubo,Guan, Fengzhi,Chen, Hongyu.

作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：黑龙江省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台