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Three novel MC4R SNPs associated with growth traits in Hu sheep and East Friesian x Hu crossbred sheep

文献类型： 外文期刊

作者： Wang, Yalei 1 ; Wang, Chunling 1 ; Zhang, Jun 2 ; Meng, Chunhua 2 ; Zhang, Xiaojian 1 ; Wang, Ziyu 1 ; Fang, Yongfei 3 ;

作者机构： 1.Nanjing Agr Univ, Coll Anim Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China

2.Jiangsu Acad Agr Sci, Inst Anim Sci, Nanjing 210014, Jiangsu, Peoples R China

3.Shanghai Yonghui Sheep Ind Co Ltd, Shanghai 201808, Peoples R China

关键词： MC4R;Sheep;SNP;Haplotype;Growth traits

期刊名称：SMALL RUMINANT RESEARCH （ 影响因子：1.611； 五年影响因子：1.813 ）

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收录情况： SCI

摘要： The melanocortin-4 receptor (MC4R) is a G-protein coupled receptor superfamily member, which has been implicated in regulating food intake, energy balance and body weight in mammals. Though the mutations of MC4R have been identified as genetic markers for growth traits in many livestock species, little is known about sheep MC4R gene. In this study, MC4R gene was amplified and sequenced to screen single nucleotide polymorphism sites (SNPs) and three novel SNPs (g.306 G>A and g.706 C>A in the coding region and g.1267 G>A in the 3'-UTR) were detected. The genetic structure of the three SNPs were examined by PCR-RFLP and CRS-PCR-RFLP, respectively, in 298 individuals of two sheep populations (Hu sheep, Hu; East Friesian x Hu crossbred sheep, EH). Association analysis between three SNPs and body traits revealed that two of the SNPs were associated with body weight, except for g.306 G>A mutation; and all three loci were significantly associated with body size. Haplotype blocks showed that there were none loci linked within Hu nor EH MC4R gene, but both generated principally seven haplotypes. Moreover, H1H3 (GA-CC-GA) diplotype had better performance than other diplotypes in Hu sheep (P < 0.05), while all of diplotypes had no significant difference in EH sheep (P > 0.05). These preliminary results indicate that three novel MC4R SNPs are related to the growth development, which may be used as genetic markers for sheep breeding and potentially afford a good foundation for further study on MC4R gene. (C) 2015 Elsevier B.V. All rights reserved.

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