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A New Cytotoxic Cytochalasin from the Endophytic Fungus Trichoderrna harzianum

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文献类型：外文期刊

作者： Chen, Huiqin ¹ ; Daletos, Georgios ¹ ; Okoye, Festus ² ; Lai, Daowan ³ ; Dai, Haofu ⁴ ; Proksch, Peter ¹ ;

作者机构： 1.Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, D-40225 Dusseldorf, Germany

2.Nnamdi Azikiwe Univ, Fac Pharmaceut Sci, Dept Pharmaceut & Med Chem, Anambra 420281, Awka Anambra St, Nigeria

3.China Agr Univ, Coll Agron & Biotechnol, Dept Plant Pathol, Beijing 100193, Peoples R China

4.Chinese Acad Trop Agr Sci, Key Lab Biol & Genet Resources Trop Crops, Inst Trop Biosci & Biotechnol, Minist Agr, Haikou 571101, Peoples R China

关键词： Trichoderma harzianum;Endophytic fungus;Cytochalasin;Cytotoxicity

期刊名称：NATURAL PRODUCT COMMUNICATIONS （影响因子：0.986；五年影响因子：1.068 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： The new natural product 4-hydroxy-deacety1-18-deoxycytochalasin H (1), together with the known deacety1-18-deoxycytochalasin H (2) and 18-deoxycytochalasin H (3) were obtained from the endophytic fungus Trichoderma harzianzim isolated from leaves of Cola nitida. The structure of the new compound was unambiguously determined by ID and 2D NNW. spectroscopy, and by HRESIMS measurements, as well as by comparison with the literature. Compounds 1-3 showed potent cytotoxic activity against the murine lymphoma (L5178Y) cell line and against human ovarian cancer (A2780 sens and A2780 CisR) cell lines (IC50 0.19-6.97 mu M). The A2780 cell lines included cisplatin-sensitive (sens) and -resistant (R) cells.

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意见箱

A New Cytotoxic Cytochalasin from the Endophytic Fungus Trichoderrna harzianum

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Comprehensive Analysis of NAC Transcription Factors Reveals Their Evolution in Malvales and Functional Characterization of AsNAC019 and AsNAC098 in Aquilaria sinensis

意 见 箱

作者其他论文更多>>

意见箱