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Development of liposomal Ganoderma lucidum polysaccharide: Formulation optimization and evaluation of its immunological activity

文献类型： 外文期刊

作者： Liu, Zhenguang 1 ; Ma, Xia 2 ; Deng, Bihua 3 ; Huang, Yee 1 ; Bo, Ruonan 1 ; Gao, Zhenzhen 1 ; Yu, Yun 1 ; Hu, Yuanliang; 1 ;

作者机构： 1.Nanjing Agr Univ, Inst Tradit Chinese Vet Med, Coll Vet Med, Nanjing 210095, Jiangsu, Peoples R China

2.Henan Univ Anim Husb & Econ, Zhengzhou 450011, Peoples R China

3.Jiangsu Acad Agr Sci, Natl Res Ct

关键词： Ganoderma lucidum polysaccharides;liposome;Optimization;Response surface methodology;Lymphocyte proliferation

期刊名称：CARBOHYDRATE POLYMERS （ 2020影响因子：9.381； 五年影响因子：8.678 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： The aim of this study was to investigate the optimizing preparation conditions of Ganoderma lucidum polysaccharide liposome (GLPL) with response surface methodology (RSM) and the immunological enhancement activity of GLPL. The immunological enhancement activity of GLPL on splenocyte proliferation was measured. The optimum formulation of GLPL, in which the ratio of soybean phospholipid to cholesterol( w/w) of 11:1, the ratio of soybean phospholipid to tween-80 (w/w) of 10.5:1 and ultrasonic time(min) of 11, had higher entrapment efficiency (EE) of 71.43 +/- 0.49% with spherical shape and uniform sizes. In addition, GLPL could significantly promote splenocyte proliferation singly or synergistically with PHA and LPS. That indicated that the immunological enhancement of Ganoderma lucidum polysaccharide (GLP) was significantly enhanced after encapsulation with the liposome. (C) 2014 Elsevier Ltd. All rights reserved.

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