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Inducing secondary metabolite production by the soil-dwelling fungus Aspergillus terreus through bacterial co-culture

文献类型： 外文期刊

作者： Chen, Huiqin 1 ; Daletos, Georgios 1 ; Abdel-Aziz, Mohamed S. 2 ; Thomy, Dhana 3 ; Dai, Haofu 4 ; Broetz-Oesterhelt 1 ;

作者机构： 1.Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, D-40225 Dusseldorf, Germany

2.Natl Res Ctr, Genet Engn & Biotechnol Div, Microbial Chem Dept, Dokki Giza 12622, Egypt

3.Univ Tubingen, Dept Microbial Bioact Cpds, Interfac Inst Microbiol & Infect Med, D-72076 Tubingen, Germany

4.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Peoples R China

5.Peking Univ, Hlth Sci Ctr, Natl Res Labs Nat & Biomimet Drugs, Beijing 100083, Peoples R China

关键词： Co-culture;Aspergillus terreus;Bacillus subtilis;Bacillus cereus;Streptomyces sp.;Butyrolactone

期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.679； 五年影响因子：1.861 ）

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收录情况： SCI

摘要： The soil-dwelling fungus Aspergillus terreus was isolated from sediment collected from the lake of Wadi EI Natrun in Egypt. Co-cultivation of A. terreus with the bacteria Bacillus subtilis and Bacillus cereus on solid rice medium resulted in an up to 34-fold increase in the accumulation of constitutively present fungal natural products (4-15) compared to axenic cultures of A. terreus. The fungal products included two new butyrolactone derivatives, isobutyrolactone II (1) and 4-O-demethylisobutyrolactone II (2), together with the known N-(carboxymethyl) anthranilic acid (3) that were not present in axenic fungal controls and were only detected during co-cultivation with B. subtilis or with B. cereus. The structures of all compounds were unambiguously elucidated by 1D and 2D NMR spectroscopy, and by HRESIMS measurements, as well as by comparison with the literature. In a second set of experiments, A. terreus was co-cultured with Streptomyces lividans and with Streptomyces coelicolor. These co-cultivation experiments failed to induce fungal natural product accumulation in contrast to co-cultures with Bacillus sp. Compounds 5 and 14 showed weak inhibition of B. cereus with minimal inhibitory concentrations (MICs) of 64 mu g/mL, whereas only 8 showed moderate cytotoxicity against the murine lymphoma (L5178Y) cell line with inhibition of 80% at a dose of 10 mu g/mL. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

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