文献类型： 外文期刊
作者： Chen, Ye 1 ; Kong, Deyang; Cai, Gengyuan 1 ; Jiang, Zhiguo 1 ; Jiao, Yiren 1 ; Shi, Yuzhen 1 ; Li, Huaqin 1 ; Wang, Ch 1 ;
作者机构： 1.South China Agr Univ, Natl Engn Res Ctr Breeding Swine Ind, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Coll Anim Sci, Guangzhou, Guangdong, Peoples R China
2.South China Agr Univ, Natl Engn Re
关键词： LiCl;Reovirus;Antiviral effect;Replication
期刊名称：MICROBIAL PATHOGENESIS （ 影响因子：3.738； 五年影响因子：3.663 ）
ISSN：
年卷期：
页码：
收录情况： SCI
摘要： Reovirus not only causes considerable economic loss in the swine industry of the United States and other countries, but also threatens the public health due to its zoonotic potential. According to previous reports, LiCl has antiviral activity against a number of viruses. The inhibitory effects of LiCl on reovirus life cycle in Vero cells were evaluated. The unpaired t-test and one-way ANOVA were used to analyze the differences between experimental groups. We first found that LiCl treatment significantly inhibited reovirus replication in a dose-dependent manner. Furthermore, we found that this antiviral activity of LiCl targets the early stage of viral replication. LiCl could be a potential drug against reovirus infection. (C) 2016 Elsevier Ltd. All rights reserved.
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