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Anti-allergic prenylated hydroquinones and alkaloids from the fruiting body of Ganoderma calidophilum

文献类型： 外文期刊

作者： Huang, Sheng Zhuo 1 ; Cheng, Bao Hui 2 ; Ma, Qing Yun 1 ; Wang, Qi 1 ; Kong, Fan Dong 1 ; Dai, Hao Fu 1 ; Qiu, Shu Qi; 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Minist Agr, Key Lab Biol & Genet Resources Trop Crops, Haikou 571101, Peoples R China

2.Inst ENT & Longgang ENT Hosp, Shenzhen Key Lab ENT, Shenzhen 511172, Peoples R China

3.Inst ENT & Longgang ENT Hosp, Shenzhen Key Lab ENT, Shenzhen 511172,

期刊名称：RSC ADVANCES （ 影响因子：3.361； 五年影响因子：3.39 ）

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收录情况： SCI

摘要： Six new prenylated hydroquinones named ganocalidin A-F (1-6) and two new compounds of ganocalicine A (7) and B (8), together with sixteen known compounds (9-24) were isolated from an EtOAc extract of the fruiting body of Ganoderma calidophilum. The new compound structures were elucidated on the basis of spectroscopic data analysis including 1D, 2D NMR and MS. Compounds 1 and 7 showed inhibitory activity effects on beta-hexosaminidase activity (IC50 9.44 and 9.14 mu M, respectively), and significantly reduced the production of IL-4 and LTB4 by RBL-2H3 cells in response to antigen stimulation, suggesting that 1 and 7 possess anti-allergic activity.

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