文献类型： 外文期刊

作者： Liao, R. ¹ ; Zhang, X. ¹ ; Chen, Q. ⁴ ; Wang, Z. ¹ ; Wang, Q. ¹ ; Yang, C. ² ; Pan, Y. ¹ ;

作者机构： 1.Shanghai Jiao Tong Univ, Sch Agr & Biol, Dept Anim Sci, Shanghai 200240, Peoples R China

2.Shanghai Acad Agr Sci, Inst Anim Husb & Vet Res, Shanghai 201106, Peoples R China

3.Shanghai Key Lab Vet Biotechnol, Shanghai 200240, Peoples R China

4.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650093, Yunnan, Peoples R China

关键词： genetics;multibreed;reduced representation sequencing;single nucleotide polymorphism

期刊名称：ANIMAL GENETICS （ 影响因子：3.169； 五年影响因子：3.058 ）

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收录情况： SCI

摘要： This study was designed to investigate the genetic basis of growth and egg traits in Dongxiang blue-shelled chickens and White Leghorn chickens. In this study, we employed a reduced representation sequencing approach called genotyping by genome reducing and sequencing to detect genome-wide SNPs in 252 Dongxiang blue-shelled chickens and 252 White Leghorn chickens. The Dongxiang blue-shelled chicken breed has many specific traits and is characterized by blue-shelled eggs, black plumage, black skin, black bone and black organs. The White Leghorn chicken is an egg-type breed with high productivity. As multibreed genome-wide association studies (GWASs) can improve precision due to less linkage disequilibrium across breeds, a multibreed GWAS was performed with 156 575 SNPs to identify the associated variants underlying growth and egg traits within the two chicken breeds. The analysis revealed 32 SNPs exhibiting a significant genome-wide association with growth and egg traits. Some of the significant SNPs are located in genes that are known to impact growth and egg traits, but nearly half of the significant SNPs are located in genes with unclear functions in chickens. To our knowledge, this is the first multibreed genome-wide report for the genetics of growth and egg traits in the Dongxiang blue-shelled and White Leghorn chickens.