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Discovery and Characterization of the Highly Active Fungal Immunomodulatory Protein Fip-vvo82

文献类型： 外文期刊

作者： Wang, Ying 1 ; Wang, Ying 1 ; Gao, Yingnv 1 ; Li, Yan 1 ; Wan, Jia-Ning 1 ; Yang, Rui-Heng 2 ; Mao, Wen-Jun; Zhou, Che 1 ;

作者机构： 1.Shanghai Acad Agr Sci, Natl Engn Res Ctr Edible Fungi, Minist Agr,Shanghai Key Lab Agr Genet & Breeding, Key Lab Appl Mycol Resources & Utilizat,Inst Edib, Shanghai 201403, Peoples R China

2.Shanghai Acad Agr Sci, Natl Engn Res Ctr Edible Fungi, Minist Agr,Shanghai

期刊名称：JOURNAL OF CHEMICAL INFORMATION AND MODELING （ 影响因子：4.956； 五年影响因子：5.39 ）

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收录情况： SCI

摘要： Volvaria volvacea (Bull. ex Fr.) Sing, an important edible and medicinal macro-fungus, has been used to remedy various diseases for hundreds of years in East Asia. To identify key proteins with the unique therapeutic activity in V. volvacea, we conducted a genomewide comparison of V. volvacea protein families and those of other edible fungi that lack therapeutic functions and identified seven fungal immunomodulatory proteins (FIPs) in V. volvacea. On the basis of the predicted physiological and biochemical characteristics of the seven FIPs, the novel Fip-vvo82 was inferred to have high immunomodulatory activity; this was confirmed by molecular and immunological experiments and further characterized by modeling the three-dimensional structure and protein-protein docking. This is the first study to show that V. volvacea has more than one FIP.

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