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Dietary safety assessment of genetically modified rice EH rich in beta-carotene

文献类型： 外文期刊

作者： Wu, Yangyang 3 ; Xu, Yan 3 ; Du, Yanan 3 ; Zhao, Xiao; Hu, Ruili 3 ; Fan, Xiaorui 3 ; Ren, Fangfang 4 ; Yao, Quanhong; 1 ;

作者机构： 1.Shanghai Acad Agr Sci, Biotechnol Res Inst, Shanghai 201106, Peoples R China

2.Shanghai Acad Agr Sci, Key Lab Agr Genet & Breeding, Shanghai, Peoples R China

3.Shanghai Normal Univ, Coll Life & Environm Sci, Shanghai, Peoples R China

4.Shanghai Normal U

关键词： B-carotene;Food safety assessment;EH rice;Transgenic rice;Toxicity assessment

期刊名称：REGULATORY TOXICOLOGY AND PHARMACOLOGY （ 影响因子：3.271； 五年影响因子：4.291 ）

ISSN： 0273-2300

年卷期： 2017 年 88 卷

页码：

收录情况： SCI

摘要： This 90-day study aimed to assess the dietary safety of transgenic rice EH which is rich in beta-carotene. Two experimental groups of Sprague-Dawley rats were fed diets containing 45% rice flour of Zhonghua 11 rice and transgenic rice EH rich in beta-carotene, respectively. The reference group was fed a diet containing standard feed nutrition. During the trial period, each rat was weighed and the food intake was recorded twice a week. Their behaviors were observed daily. In the end, blood samples were obtained from all anesthetized rats to measure the hematologic and serum chemistry indicators. Growth performance, anatomy and pathology of all organs in each group were analyzed. Although a few parameters were found to be statistically significantly different across groups, they were within the normal reference range for this breed and age of rats. Therefore, the changes were not considered to be diet related. The results revealed that the transgenic rice EH rich in beta-carotene was as nutritious as Zhonghua 11 rice and showed a lack of biologically meaningful unintended effects. (C) 2017 Elsevier Inc. All rights reserved.

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