Purification and Characterization of a Novel Small-Molecule Polysaccharide from the Maitake Medicinal Mushroom Grifola frondosa (Higher Basidiomycetes)
文献类型: 外文期刊
作者: Zhou, Changyan 1 ; Qiao, Yanru 3 ; Tang, Qingjiu 3 ; Jia, Wei 3 ; Liu, Yanfang 3 ; Wu, Aizhong 1 ;
作者机构: 1.Shanghai Jiao Tong Univ, Sch Agr & Biol, Shanghai 200240, Peoples R China
2.Shanghai Acad Agr Sci, Inst Agrifood Stand & Testing Technol, Shanghai, Peoples R China
3.Shanghai Acad Agr Sci, Inst Edible Fungi, Shanghai, Peoples R China
4.Southwest Univ, Coll Pharmaceut Sci, Chongqing, Peoples R China
关键词: medicinal mushrooms;Maitake mushroom;Grifola frondosa;small-molecule polysaccharide;purification;immune activity;macrophages
期刊名称:INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS ( 影响因子:1.921; 五年影响因子:1.879 )
ISSN: 1521-9437
年卷期: 2013 年 15 卷 2 期
页码:
收录情况: SCI
摘要: A novel small-molecule polysaccharide with a molecular mass of 2.6 kDa, was isolated from the culinary-medicinal Maitake mushroom Grifold frondosa. GFPS is composed of facose, rhamnose, galactose, glucose, and mannose; galactose, glucose, and mannose were the dominant monosaccharides. Absorption peaks at 1077 cm(-1), 1024 cm(-1), and 873 cm(-1), as revealed by infrared spectrum, suggesting that GFPS consists of pyranoside. GFPS significantly enhanced the production of nitric oxide and secretion of cytokines (tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6) from macrophages in vitro. These results indicate that this novel small-molecule polysaccharide might be beneficial for immune defense.
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