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Inhibitory effects of recombinant porcine interferon-alpha on high- and low-virulence porcine reproductive and respiratory syndrome viruses

文献类型： 外文期刊

作者： Dong, Shijuan 1 ; Yin, Yanbo 3 ; Shen, Shiyuan 1 ; Guo, Yanyan 4 ; Gao, Minjie; Zhang, Wanhua 1 ; Zhu, Yumin 1 ; Yu, R 1 ;

作者机构： 1.Shanghai Acad Agr Sci, Inst Anim Sci & Vet Med, Shanghai 201106, Peoples R China

2.Shanghai Key Lab Agr Genet & Breeding, Shanghai 201106, Peoples R China

3.Qingdao Agr Univ, Coll Anim Sci & Vet Med, Qingdao 266109, Shandong, Peoples R China

4.Qingdao Agr Univ, Coll Anim Sci & Vet Med, Qingdao 266109, Shandong, Peoples R Ch

关键词： Interferon-alpha;Porcine respiratory and reproduction syndrome;Virus;Challenge;Lymphocyte;Immunology

期刊名称：RESEARCH IN VETERINARY SCIENCE （ 影响因子：2.534； 五年影响因子：2.382 ）

ISSN： 0034-5288

年卷期： 2012 年 93 卷 2 期

页码：

收录情况： SCI

摘要： The inhibitory effects of recombinant porcine interferon alpha (rPolFN-alpha) on the propagation of low-virulence PRRSV (IvPRRSV) in MARC-145 cells, and on the progress and severity of high virulence PRRSV (hvPRRSV)-induced infections in pigs, were determined. Pre-treatment of MARC-145 cells with increasing concentrations of rPolFN-alpha prior to infection with IvPRRSV decreased the observed cytopathic effects (CPEs) in a concentration-dependent manner. Viral propagation and antibody response were temporarily delayed in swine treated with rPolFN-alpha either at the same time as the hvPRRSV challenge was administered or post-challenge. Exposure of challenged animals to rPolFN-alpha after the onset of disease symptoms alleviated associated hyperthermia. Variations in lymphocyte subsets indicated that rPolFN-alpha treatment might alleviate damage to the immune system or enhance propagation of host cytotoxic T-lymphocytes when the treatment was applied simultaneously with the virus or 1 dpc, respectively. (C) 2011 Elsevier Ltd. All rights reserved.

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