Environmentally relevant concentrations of tralopyril affect carbohydrate metabolism and lipid metabolism of zebrafish (Danio rerio) by disrupting mitochondrial function
文献类型： 外文期刊
作者： Chen, Xiangguang 1 ; Zheng, Junyue 1 ; Teng, Miaomiao 2 ; Zhang, Jie 1 ; Qian, Le 1 ; Duan, Manman 1 ; Wang, Zhao 3 ; Wan 1 ;
作者机构： 1.China Agr Univ, Coll Sci, Dept Appl Chem, Innovat Ctr Pesticide Res, Beijing 100193, Peoples R China
2.Chinese Res Inst Environm Sci, State Key Lab Environm Criteria & Risk Assessment, Beijing 100012, Peoples R China
3.Jilin Acad Agr Sci, Inst Plant Prod, Changchun 130033, Peoples R China
关键词： Tralopyril; Carbohydrate metabolism; Lipid metabolism; Mitochondrial respiratory complexes
期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.291； 五年影响因子：6.393 ）
ISSN： 0147-6513
年卷期： 2021 年 223 卷
页码：
收录情况： SCI
摘要： Tralopyril (TP), an antifouling biocide, is widely used to prevent heavy biofouling, and can have potential risks to aquatic organisms. However, there is little information available on the toxicity of tralopyril to aquatic organisms. In this study, the effect of TP on carbohydrate and lipid metabolism, and related mechanisms were evaluated in zebrafish (Danio rerio) larvae. Adverse modifications in carbohydrate metabolism were observed in larvae: hexokinase (HK) activity, succinate dehydrogenase (SDH) activity, and adenosine triphosphate (ATP) content were significantly decreased; and transcript expression of genes (GK, HK1, and PCK1) was also significantly changed. Changes of TG content, FAS activity and transcript expression of genes (ACO, ehhadh, and fas) indicate that TP disrupt lipid metabolism in zebrafish larvae. The change in expression of genes (ndufs4, Sdh alpha, and uqcrc2) involved in the mitochondrial respiratory complexes, and genes (polg1 and tk2) involved in the mitochondrial DNA replication and transcription indicates that these adverse effects on carbohydrate and lipid metabolism are caused by mitochondrial dysfunction.
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