Synthesis of Fused pyrazolo[4,3-c]quinolines through KI-Promoted Cyclization of Pyrazole-arylamines and Benzyl Bromide
文献类型： 外文期刊
作者： Mu, Yangxiu 1 ; Iqbal, Zafar 1 ; Jiang, Rui 1 ; Hou, Jing 1 ; Yang, Zhixiang 1 ; Li, Hongjun 2 ; Tang, Dong 1 ;
作者机构： 1.Ningxia Acad Agr & Forestry Sci, Agr Resource & Environm Inst, Ningxia Ctr Agr Organ Synth, Yinchuan 750002, Ningxia, Peoples R China
2.Ningxia Acad Metrol & Qual Inspect, Natl Measurement & Testing Ctr Coal Chem Ind, Yinchuan 750002, Ningxia, Peoples R China
关键词： Pyrazolo[4; 3-c]quinoline; 2-(1H-pyrazol-5-yl)anilines; Benzyl bromide; Potassium iodide; Fused heterocycle
期刊名称：CHEMISTRYSELECT （ 影响因子：2.307； 五年影响因子：2.112 ）
ISSN： 2365-6549
年卷期： 2022 年 7 卷 10 期
页码：
收录情况： SCI
摘要： A simple and highly efficient protocol was developed for the formation of pyrazolo[4,3-c]quinolines starting from 2-(1H-pyrazol-5-yl)anilines and benzyl bromide in the presence of KI, affording desired products in moderate to good yields. The reaction showed good tolerance for a range of substrates with variable substituents. In this methodolgy, benzyl bromide proved to be an available C1 synthon in organic synthesis. Moreover, benzyl bromide can be replaced with benzyl iodide to synthesize pyrazolo[4,3-c]quinoline derivatives, and benzyl chloride could not apply in this reaction system.
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