Dynamic intrauterine crosstalk promotes porcine embryo implantation during early pregnancy
文献类型： 外文期刊
作者： Zang, Xupeng 1 ; Gu, Shengchen 1 ; Wang, Wenjing 1 ; Shi, Junsong 3 ; Gan, Jianyu 1 ; Hu, Qun 1 ; Zhou, Chen 1 ; Ding, Yue 1 ; He, Yanjuan 1 ; Jiang, Lei 1 ; Gu, Ting 1 ; Xu, Zheng 1 ; Huang, Sixiu 1 ; Yang, Huaqiang 1 ; Meng, Fanming 4 ; Li, Zicong 1 ; Cai, Gengyuan 1 ; Hong, Linjun 1 ; Wu, Zhenfang 1 ;
作者机构： 1.South China Agr Univ, Coll Anim Sci, Natl Engn Res Ctr Breeding Swine Ind, State Key Lab Swine & Poultry Breeding Ind, Guangzhou 510642, Peoples R China
2.South China Agr Univ, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangzhou 510642, Peoples R China
3.Yunfu Subctr Guangdong Lab Lingnan Modern Agr, Yunfu 527300, Peoples R China
4.Guangdong Acad Agr Sci, Inst Anim Sci, Guangdong Key Lab Anim Breeding & Nutr, Guangzhou 510640, Peoples R China
5.Minist Agr & Rural Affairs, Key Lab South China Modern Biol Seed Ind, Guangzhou 510520, Peoples R China
关键词： endometrial remodeling; ExtraCellTalk; implantation; maternal-foetal crosstalk; trophoblast
期刊名称：SCIENCE CHINA-LIFE SCIENCES （ 影响因子：9.1； 五年影响因子：7.1 ）
ISSN： 1674-7305
年卷期： 2024 年
页码：
收录情况： SCI
摘要： Dynamic crosstalk between the embryo and mother is crucial during implantation. Here, we comprehensively profile the single-cell transcriptome of pig peri-implantation embryos and corresponding maternal endometrium, identifying 4 different lineages in embryos and 13 cell types in the endometrium. Cell-specific gene expression characterizes 4 distinct trophectoderm subpopulations, showing development from undifferentiated trophectoderm to polar and mural trophectoderm. Dynamic expression of genes in different types of endometrial cells illustrates their molecular response to embryos during implantation. Then, we developed a novel tool, ExtraCellTalk, generating an overall dynamic map of maternal-foetal crosstalk using uterine luminal proteins as bridges. Through cross-species comparisons, we identified a conserved RBP4/STRA6 pathway in which embryonic-derived RBP4 could target the STRA6 receptor on stromal cells to regulate the interaction with other endometrial cells. These results provide insight into the maternal-foetal crosstalk during embryo implantation and represent a valuable resource for further studies to improve embryo implantation.
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