文献类型： 外文期刊
作者： Tao, Wenjing 1 ; Fan, Qiwen 1 ; Wei, Jintao 1 ;
作者机构： 1.Hubei Acad Agr Sci, Inst Anim Husb & Vet, Hubei Key Lab Anim Embryo & Mol Breeding, Wuhan 430064, Peoples R China
关键词： drug-induced liver injury; gut-liver axis; gut microbiota; metabolites; bile acid
期刊名称：CURRENT ISSUES IN MOLECULAR BIOLOGY （ 影响因子：3.1； 五年影响因子：3.3 ）
ISSN： 1467-3037
年卷期： 2024 年 46 卷 2 期
页码：
收录情况： SCI
摘要： Drug-induced liver injury (DILI) is a liver disease that remains difficult to predict and diagnose, and the underlying mechanisms are yet to be fully clarified. The gut-liver axis refers to the reciprocal interactions between the gut and the liver, and its homeostasis plays a prominent role in maintaining liver health. It has been recently reported that patients and animals with DILI have a disrupted gut-liver axis, involving altered gut microbiota composition, increased intestinal permeability and lipopolysaccharide translocation, decreased short-chain fatty acids production, and impaired bile acid metabolism homeostasis. The present review will summarize the evidence from both clinical and preclinical studies about the role of the gut-liver axis in the pathogenesis of DILI. Moreover, we will focus attention on the potential therapeutic strategies for DILI based on improving gut-liver axis function, including herbs and phytochemicals, probiotics, fecal microbial transplantation, postbiotics, bile acids, and Farnesoid X receptor agonists.
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