Vitamin D-3 modulates yellow catfish (Pelteobagrus fulvidraco) immune function in vivo and in vitro and this involves the vitamin D-3/VDR-type I interferon axis
文献类型： 外文期刊
作者： Cheng, Ke 1 ; Ma, Chunsong 1 ; Guo, Xun 1 ; Huang, Yanqing 2 ; Tang, Rong 1 ; Karrow, Niel A. 3 ; Wang, Chunfang 1 ;
作者机构： 1.Huazhong Agr Univ, Coll Fisheries, Freshwater Aquaculture Collaborat Innovat Ctr Hub, Hubei Prov Engn Lab Pond Aquaculture, Wuhan 430070, Peoples R China
2.Chinese Acad Fishery Sci, East China Sea Fisheries Res Inst, Shanghai 200090, Peoples R China
3.Univ Guelph, Dept Anim Biosci, Guelph, ON N1G 2W1, Canada
关键词： Yellow catfish; Vitamin D-3; Immune response; In vivo; In vitro; VD3/VDR-Type I interferon action axis
期刊名称：DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY （ 影响因子：3.636； 五年影响因子：3.654 ）
ISSN： 0145-305X
年卷期： 2020 年 107 卷
页码：
收录情况： SCI
摘要： Vitamin D-3 (VD3) has been shown to regulate immune function in mammals. 1,25-dihydroxyvitamin (1,25(OH)(2)D-3) is the active form of vitamin D-3, which is also known as calcitriol. The current study investigated the immunomodulatory effects of 1,25(OH)(2)D-3 on the innate immune response of yellow catfish (Pelteobagrus fulvidraco) after in vivo and in vitro immune challenge. The in vivo results showed that increasing dietary vitamin D-3 decreased mortality, enhanced the immune protective rate, and increased serum lysozyme, catalase and SOD activities in yellow catfish infected with Edwardsiella Ictaluri (p < 0.05). The in vitro results showed that 1,25(OH)(2)D-3 (0, 1, 10, 100, 200 pM) dose-dependently attenuated the rate of apoptosis and production or reactive oxygen species and increased the phagocytic activity of head kidney macrophages stimulated with 10 mg/L lipopolysaccharide (LPS) and 100 mg/L of Poly(I:C) (p < 0.05). Real-time quantitative PCR results showed that increasing dietary vitamin D3 content in vivo and increasing the level of 1,25(OH)(2)D-3 in vitro partially regulated the expression of VD3/VDR-type I interferon axis genes (vdr, irf-3, ifn-a, jak1, stat1, ifi56 and ifp35) after immune challenge. These results indicated that vitamin D-3 content helped yellow catfish to resist oxidative stress and inflammation caused by immune challenge, and immunomodulation involved the VD3/VDRtype I interferon action axis.
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