Iron-Catalyzed Synthesis of Polyfunctional Pyridines from Ketoxime Carboxylates and Nitrones
文献类型： 外文期刊
作者： Jiang, Rui 1 ; Liu, Xiang 2 ; Mu, Yangxiu 1 ; Iqbal, Zafar 1 ; He, Lili 1 ; Zhai, Lijuan 1 ; Hou, Jing 1 ; Yang, Minghua; 1 ;
作者机构： 1.Ningxia Acad Agr & Forestry Sci, Agr Resource & Environm Inst, Ningxia Ctr Agr Organ Synth, Yinchuan 750002, Ningxia, Peoples R China
2.China Three Gorges Univ, Coll Mat & Chem Engn, Yichang 443002, Hubei, Peoples R China
3.Lishui Univ, Dept Chem, Lishui 323000, Peoples R China
关键词： C1 unit; Iron-catalyzed; Ketoxime carboxylates; Polyfunctional pyridines; Nitrones
期刊名称：CHEMISTRYSELECT （ 影响因子：2.109； 五年影响因子：2.054 ）
ISSN： 2365-6549
年卷期： 2020 年 5 卷 15 期
页码：
收录情况： SCI
摘要： Polyfunctional pyridines are backbone of numerous natural products and pharmaceutical reactive intermediates. We have developed an iron-catalyzed cyclization reaction between ketoxime carboxylates and nitrones to afford trisubstituted pyridines. Employing this strategy, we have synthesized a number of trisubstituted pyridines with various functional groups in good yields under simple reaction conditions. It is worth mentioning that the nitrones can serve as a novel C1 unit in organic synthesis.
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