Ene-yne Hydroquinones from a Marine-derived Strain of the Fungus Pestalotiopsis neglecta with Effects on Liver X Receptor Alpha
文献类型： 外文期刊
作者： Wang, Jianjiao 2 ; Liang, Zhi 1 ; Li, Kunlong 2 ; Yang, Bin 2 ; Liu, Yonghong 2 ; Fang, Wei 3 ; Tang, Lan 1 ; Zhou, Xuefe 1 ;
作者机构： 1.Southern Med Univ, Guangdong Prov Key Lab New Drug Screening, Biopharmaceut, Sch Pharmaceut Sci, Guangzhou 510515, Peoples R China
2.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Peoples R China
3.Hubei Acad Agr Sci, Hubei Biopesticide Engn Res Ctr, Wuhan 430064, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：4.05； 五年影响因子：4.603 ）
ISSN： 0163-3864
年卷期： 2020 年 83 卷 4 期
页码：
收录情况： SCI
摘要： Seven unusual new ene-yne hydroquinones (1-3, 5-8), including three rare glycosylated derivatives named pestalotioquinosides A-C (6-8), were obtained from the marine-derived strain SCSIO41403 of the fungus Pestalotiopsis neglecta. Their structures including absolute configurations were elucidated by spectroscopic analysis and induced electronic circular dichroism experiments. In silico molecular docking and in vitro surface plasmon resonance studies showed that pestalotioquinoside C (8) could act as a liver X receptor alpha (LXR alpha) modulator. Further study showed that LXR target gene ABCA1 was significantly upregulated by 8, which revealed 8 as a potential LXR alpha agonist.
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