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Breviscapine suppresses the growth and metastasis of prostate cancer through regulating PAQR4-mediated PI3K/Akt pathway

文献类型： 外文期刊

作者： Ye, Jiwei 1 ; Gao, Mingquan 2 ; Guo, Xinwu 1 ; Zhang, Henan 3 ; Jiang, Fuchun 4 ;

作者机构： 1.Nanyang Second Peoples Hosp Henan Prov, Dept Urol, Nanyang 473000, Henan, Peoples R China

2.Univ Elect Sci & Technol China, Sch Med, Sichuan Canc Hosp, Chengdu 610041, Sichuan, Peoples R China

3.Shanghai Acad Agr Sci, Natl Engn Res Ctr Edible Fungi, Key Lab Edible Fungi Resources & Utilizat South, Inst Edible Fungi,Minist Agr, Shanghai 201403, Peoples R China

4.Second Mil Med Univ, Sch Pharm, Dept Pharmaceut Bot, Shanghai 200433, Peoples R China

关键词： Prostate cancer; Breviscapine; PAQR4; PI3K/Akt pathway; Proliferation; Metastasis

期刊名称：BIOMEDICINE & PHARMACOTHERAPY （ 影响因子：6.529； 五年影响因子：5.979 ）

ISSN： 0753-3322

年卷期： 2020 年 127 卷

页码：

收录情况： SCI

摘要： Objectives: Prostate cancer, one of the most frequently diagnosed tumors of men, leads to poor quality of life. Previous studies have shown that breviscapine (BRE) exerts therapeutic activity in malignant tumors. However, the role and mechanism of BRE exhibit an anti-tumor effect on prostate cancer are largely unknown. Methods: The mRNA and protein levels in prostate cancer tissues and cell lines were measured using RT-qPCR, western blot, and immunohistochemical staining, respectively. Cell proliferation, invasion, and migration in both PC3 and DU145 cells were evaluated using CCK-8 and Transwell assay. The effect of BRE on cell proliferation and metastasis by regulating the PAQR4-mediated PI3K/Akt pathway in vitro and in vivo was determined. Results: PAQR4 was significantly overexpressed in prostate cancer tissues and cell lines, which was positively correlated with poor prognosis. Knockdown of PAQR4 inhibited the proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT) of both PC3 and DU145 cells. Mechanistically, BRE treatment significantly suppressed the malignant biological behavior of both prostate cancer cells by downregulating PAQR4 and blocking the PI3K/Akt pathway. In vivo experiments, BRE administration remarkably inhibited tumor growth and metastasis in a xenograft model of prostate cancer. Conclusion: Our findings revealed that BRE exerts anti-tumor and anti-metastasis roles in prostate cancer by inhibiting PAQR4-mediated PI3K/Akt pathway, which provides a new therapeutic agent for prostate cancer clinical treatment.

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