文献类型： 外文期刊
作者： Xu, Dongbo 1 ; Tian, Erli 1 ; Kong, Fandong 2 ; Hong, Kui 1 ;
作者机构： 1.Wuhan Univ, Sch Pharmaceut Sci, Key Lab Combinatorial Biosynth & Drug Discovery, Minist Educ, Wuhan 430071, Peoples R China
2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Hainan, Peoples R China
关键词： mangrove Streptomyces; genetic dereplication; anti-microbial; antiproliferative
期刊名称：MARINE DRUGS （ 影响因子：5.118； 五年影响因子：5.951 ）
ISSN：
年卷期： 2020 年 18 卷 5 期
页码：
收录情况： SCI
摘要： Five new compounds 15R-17,18-dehydroxantholipin (1), (3E,5E,7E)-3-methyldeca-3,5,7-triene-2,9-dione (2) and qinlactone A-C (3-5) were identified from mangrove Streptomyces qinglanensis 172205 with "genetic dereplication," which deleted the highly expressed secondary metabolite-enterocin biosynthetic gene cluster. The chemical structures were established by spectroscopic methods, and the absolute configurations were determined by electronic circular dichroism (ECD). Compound 1 exhibited strong anti-microbial and antiproliferative bioactivities, while compounds 2-4 showed weak antiproliferative activities.
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