Anti-inflammatory spirobisnaphthalene natural products from a plant-derived endophytic fungus Edenia gomezpompae
文献类型： 外文期刊
作者： Tan, Yingzi 1 ; Guo, Zhikai 2 ; Zhu, Mengyue 1 ; Shi, Jing 1 ; Li, Wei 1 ; Jiao, Ruihua 1 ; Tan, Renxiang 1 ; Ge, Huiming 1 ;
作者机构： 1.Nanjing Univ, Inst Funct Biomol, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Peoples R China
2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab Trop Microbe Resources, Haikou 571101, Hainan, Peoples R China
3.Nanjing Univ Chinese Med, State Key Lab Cultivat Base TCM Qual & Efficacy, Nanjing 210023, Peoples R China
4.Chinese Acad Trop Agr Sci, Hainan Acad Trop Agr Resource, Haikou 571101, Hainan, Peoples R China
关键词： Endophytic fungus; Spirobisnaphthalene natural products; Preussomerin-type; Structure elucidation; Anti-inflammatory activity
期刊名称：CHINESE CHEMICAL LETTERS （ 影响因子：6.779； 五年影响因子：4.558 ）
ISSN： 1001-8417
年卷期： 2020 年 31 卷 6 期
页码：
收录情况： SCI
摘要： Spirobisnaphthalenes comprise a relatively rare family of natural products that are normally isolated from fungi and occasionally from plants. Here we reported the discovery of seven new preussomerin-type spirobisnaphthalenes, preussomerins YT1-YT7 (1-7), and seven known ones (8-14), from the endophytic fungus Edenia gomezpompae, enriching the structural diversity of this family of natural products. Their structures were established by 1D and 2D NMR spectroscopy, HRESIMS analysis and comparison with previously reported compounds, with the absolute configurations of compounds 1 and 2 being further confirmed by single-crystal X-ray diffraction using Cu K alpha radiation. The anti-inflammatory activities of all isolates were assessed by measuring the production of NO in LPS-induced RAW264.7 macrophage cells. Among them, compounds 8 and 13 exhibited potent inhibitory activities on the production of NO, with IC50 values of 2.61 and 1.32 mu mol/L, respectively. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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