New evidence for SPX2 in regulating the brain-pituitary reproductive axis of half-smooth tongue sole (Cynoglossus semilaevis)
文献类型： 外文期刊
作者： Wang, Bin 1 ; Wang, Kaijie 1 ; Tian, Zhenfang 1 ; Cui, Aijun 1 ; Liu, Xin 1 ; Jin, Zhixin 1 ; Liu, Xuezhou 1 ; Jiang, Yan 1 ; Xu, Yongjiang 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Key Lab Sustainable Dev Marine Fisheries, Minist Agr & Rural Affairs, Qingdao, Peoples R China
2.Joint Lab Deep Blue Fishery Engn, Pilot Natl Lab Marine Sci & Technol Qingdao, Qingdao, Peoples R China
3.Zhejiang Ocean Univ, Natl Engn Res Ctr Marine Aquaculture, Zhoushan, Peoples R China
4.Tianjin Agr Univ, Coll Fisheries, Tianjin, Peoples R China
5.Dalian Ocean Univ, Coll Fisheries & Life Sci, Dalian, Peoples R China
关键词： spexin; GnIH; GnRH; kisspeptin; gonadotropin; reproduction
期刊名称：FRONTIERS IN ENDOCRINOLOGY （ 影响因子：6.055； 五年影响因子：6.335 ）
ISSN： 1664-2392
年卷期： 2022 年 13 卷
页码：
收录情况： SCI
摘要： Spexin (SPX) is an evolutionarily conserved neuropeptide, which was first identified in human proteome by data mining. Two orthologs (SPX1 and SPX2) are present in some non-mammalian species, including teleosts. It has been demonstrated that SPX1 is involved in reproduction and food intake, whereas the functional role of SPX2 is still absent in any vertebrate. The aim of the current study was to evaluate the actions of intraperitoneal injection of endogenous SPX2 peptide on the expression levels of some key reproductive genes of the brain-pituitary axis in half-smooth tongue sole. Our data showed an inhibitory action of SPX2 on brain gnih, spx1, tac3 and pituitary gth alpha, lh beta mRNA levels. However, SPX2 had no significant effect on brain gnihr, gnrh2, gnrh3, kiss2, kiss2r, spx2 expression or pituitary gh expression. On the other hand, SPX2 induced an increase in pituitary fsh beta expression. Taken together, our results provide initial evidence for the involvement of SPX2 in the regulation of reproduction in vertebrates, which is in accordance with previous studies on SPX1.
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