您好，欢迎访问湖北省农业科学院 机构知识库！
湖北省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Bioactive Polyketides and Benzene Derivatives from Two Mangrove Sediment-Derived Fungi in the Beibu Gulf

文献类型： 外文期刊

作者： Peng, Bo 1 ; Cai, Jian 2 ; Xiao, Zimin 3 ; Liu, Manli 4 ; Li, Xinlong 2 ; Yang, Bin 2 ; Fang, Wei 4 ; Huang, Yi-You 5 ; Chen, Chunmei 2 ; Zhou, Xuefeng 2 ; Tao, Huaming 3 ;

作者机构： 1.Jinan Univ, Inst Environm & Climate Res, Guangzhou 511443, Peoples R China

2.Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Peoples R China

3.Southern Med Univ, Sch Tradit Chinese Med, Guangdong Prov Key Lab Chinese Med Pharmaceut, Guangzhou 510515, Peoples R China

4.Hubei Acad Agr Sci, Hubei Biopesticide Engn Res Ctr, Wuhan 430064, Peoples R China

5.Hainan Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Trop Biol Resources, Haikou 570228, Peoples R China

关键词： mangrove sediment-derived fungi; polyketide; stachylines; biological activity

期刊名称：MARINE DRUGS （ 影响因子：5.4； 五年影响因子：5.5 ）

ISSN：

年卷期： 2023 年 21 卷 6 期

页码：

收录情况： SCI

摘要： To discover bioactive natural products from mangrove sediment-derived microbes, a chemical investigation of the two Beibu Gulf-derived fungi strains, Talaromyces sp. SCSIO 41050 and Penicillium sp. SCSIO 41411, led to the isolation of 23 natural products. Five of them were identified as new ones, including two polyketide derivatives with unusual acid anhydride moieties named cordyanhydride A ethyl ester (1) and maleicanhydridane (4), and three hydroxyphenylacetic acid derivatives named stachylines H-J (10-12). Their structures were determined by detailed nuclear magnetic resonance (NMR) and mass spectroscopic (MS) analyses, while the absolute configurations were established by theoretical electronic circular dichroism (ECD) calculation. A variety of bioactive screens revealed three polyketide derivatives (1-3) with obvious antifungal activities, and 4 displayed moderate cytotoxicity against cell lines A549 and WPMY-1. Compounds 1 and 6 at 10 & mu;M exhibited obvious inhibition against phosphodiesterase 4 (PDE4) with inhibitory ratios of 49.7% and 39.6%, respectively, while 5, 10, and 11 showed the potential of inhibiting acetylcholinesterase (AChE) by an enzyme activity test, as well as in silico docking analysis.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：湖北省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台