Phenolic profile, antioxidation and anti-proliferation activity of phenolic-rich extracts from Sanghuangporus vaninii
文献类型： 外文期刊
作者： Gao, Hong 1 ; Yin, Chaomin 1 ; Li, Chen 1 ; Li, Yuhong 1 ; Shi, Defang 1 ; Fan, Xiuzhi 1 ; Yao, Fen 1 ; Wu, Wenjing 1 ; Li, Jiangtao 3 ;
作者机构： 1.Hubei Acad Agr Sci, Minist Agr & Rural Affairs, Inst Agroprod Proc & Nucl Agr Technol, Natl Res & Dev Ctr Edible Fungi Proc Wuhan,Key Lab, Wuhan 430064, Peoples R China
2.Res Ctr Under Forest Econ Hubei Prov, Wuhan 430064, Peoples R China
3.Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Changsha 410004, Peoples R China
4.Hubei Acad Agr Sci, Inst Agroprod Proc & Nucl Agr Technol, Wuhan 430064, Peoples R China
关键词： Sanghuangporus vaninii; Phenolic profile; Polyphenols; Antioxidative activity; Antiproliferative activity
期刊名称：CURRENT RESEARCH IN FOOD SCIENCE （ 影响因子：6.3； 五年影响因子：6.3 ）
ISSN：
年卷期： 2023 年 6 卷
页码：
收录情况： SCI
摘要： In this study, phenolic-rich extracts from Sanghuangporus vaninii (SHE) were prepared, the phenolic profile and main phenolic compound content of SHE were studied by UPLC-Orbitrap-MS, and the antioxidant and antiproliferation activities of SHE were evaluated. The results showed that the total polyphenol content and the total flavonoid content of SHE were 42.420 & PLUSMN; 0.011 mg GAE/g EW and 8.504 & PLUSMN; 0.205 mg RE/g EW, respectively. Moreover, 14 phenolic acids and 8 flavonoids in SHE were identified, among which, the major polyphenols were protocatechualdehyde (394.68 & mu;g/g), protocatechuic acid (196.88 & mu;g/g), caffeic acid (96.11 & mu;g/g), L-phenylalanine (12.72 & mu;g/g) and (+)-taxifolin (8.59 & mu;g/g). SHE showed strong radical scavenging, anti-lipid peroxidation and anti-DNA damage capacity in vitro. SHE could effectively induce HepG2 cell apoptosis via the caspases-dependent mitochondrial apoptotic pathway and arrest the cell cycle in the G0/G1 phase. The present study suggested that S. vaninii could be a valuable source of natural antioxidative and antiproliferative ingredients.
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