文献类型： 外文期刊
作者： Meng, Jiajia 1 ; Li, Ruijiao 1 ; Zhang, Zhiqi 1 ; Wang, Jie 1 ; Huang, Qingwen 1 ; Nie, Dongxia 1 ; Fan, Kai 1 ; Guo, Wenbo 1 ; Zhao, Zhihui 1 ; Han, Zheng 1 ;
作者机构： 1.Shanghai Acad Agr Sci, Inst Agro Food Stand & Testing Technol, Shanghai 201403, Peoples R China
2.Univ Shanghai Sci & Technol, Sch Hlth Sci & Engn, Shanghai 200093, Peoples R China
关键词： SARS-CoV-2; coronavirus; COVID-19; therapeutic strategies; pathogenesis
期刊名称：VIRUSES-BASEL （ 影响因子：5.818； 五年影响因子：5.811 ）
ISSN：
年卷期： 2022 年 14 卷 11 期
页码：
收录情况： SCI
摘要： Coronavirus disease 2019 is a rather heterogeneous disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The ongoing pandemic is a global threat with increasing death tolls worldwide. SARS-CoV-2 belongs to lineage B beta-CoV, a subgroup of Sarbecovirus. These enveloped, large, positive-sense single-stranded RNA viruses are easily spread among individuals, mainly via the respiratory system and droplets. Although the disease has been gradually controlled in many countries, once social restrictions are relaxed the virus may rebound, leading to a more severe and uncontrollable situation again, as occurred in Shanghai, China, in 2022. The current global health threat calls for the urgent development of effective therapeutic options for the treatment and prevention of SARS-CoV-2 infection. This systematic overview of possible SARS-CoV-2 therapeutic strategies from 2019 to 2022 indicates three potential targets: virus entry, virus replication, and the immune system. The information provided in this review will aid the development of more potent and specific antiviral compounds.
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