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Function of Litopenaeus vannamei RPL4A-L and RPS16 in WSSV infection

文献类型： 外文期刊

作者： Ren, Xing-Chao 1 ; Wan, Xiao-Yuan 1 ; Liu, Qing-Hui 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Qingdao Key Lab Mariculture Epidemiol & Biosecur, Key Lab Maricultural Organism Dis Control, Yellow Sea Fisheries Res Inst,Minist Agr, Qingdao, Peoples R China

2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Jimo, Peoples R China

关键词： Litopenaeus vannamei; LvRPL4-L; LvRPS16; WSSV; Immune response

期刊名称：AQUACULTURE REPORTS （ 影响因子：3.216； 五年影响因子：3.812 ）

ISSN： 2352-5134

年卷期： 2021 年 21 卷

页码：

收录情况： SCI

摘要： Ribosome, as basic components of the protein synthesis machinery, plays an important role in normal cellular physiology, cellular responses and pathogenesis. Ribosome consists of a large subunit (60S) and a small subunit (40S). In Litopenaeus vannamei (L. vannamei), the function of the 60S ribosome protein L4A-Like (LvRPL4A-L) and the 40S ribosome protein S16 (LvRPS16) in white spot syndrome virus (WSSV) infection was unclear. In the present study, the tissue distribution assay showed that LvRPL4-L and LvRPS16 were expressed in all selected tissues. The expressions of LvRPL4-L and LvRPS16 at the mRNA level were mainly distributed in the muscle, stomach, and hepatopancreas. Besides, the relative expressions of LvRPL4-L and LvRPS16 were up-regulated in the hepatopancreas and stomach of WSSV-challenged shrimp. In addition, after LvRPL4-L or LvRPS16 silencing and WSSV infection, the relative expressions of immediate early gene IE1 and late gene VP28 were significantly up-regulated. Meanwhile, compared with the control group, the viral copy number and cumulative mortality rate of the LvRPL4-L- or LvRPS16-silenced group were also significantly increased. We, for the first time, reported the function of LvRPL4-L and LvRPS16 in the antiviral immune response of L. vannamei.

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