Cross-Species Insights into Trophoblast Invasion During Placentation Governed by Immune-Featured Trophoblast Cells
文献类型： 外文期刊
作者： Zang, Xupeng 1 ; Zhang, Dan 2 ; Wang, Wenjing 1 ; Ding, Yue 1 ; Wang, Yongzhong 1 ; Gu, Shengchen 1 ; Shang, Yijun 1 ; Gan, Jianyu 1 ; Jiang, Lei 1 ; Meng, Fanming 3 ; Shi, Junsong 4 ; Xu, Zheng 1 ; Huang, Sixiu 1 ; Li, Zicong 1 ; Wu, Zhenfang 1 ; Gu, Ting 1 ; Cai, Gengyuan 1 ; Hong, Linjun 1 ;
作者机构： 1.South China Agr Univ, Natl Engn Res Ctr Breeding Swine Ind, State Key Lab Swine & Poultry Breeding Ind, Coll Anim Sci,Guangdong Prov Key Lab Agroanim Geno, Guangzhou 510642, Peoples R China
2.Sun Yat Sen Univ, Affiliated Hosp 1, Reprod Med Ctr, Guangdong Prov Key Lab Reprod Med, Guangzhou 510080, Peoples R China
3.Guangdong Acad Agr Sci, Inst Anim Sci, Guangdong Key Lab Anim Breeding & Nutr, Guangzhou 510640, Peoples R China
4.Yunfu Subctr Guangdong Lab Lingnan Modern Agr, Yunfu 527300, Peoples R China
5.Minist Agr & Rural Affairs, Key Lab South China Modern Biol Seed Ind, Guangzhou 510520, Peoples R China
关键词： iTrophoblast; placentation; preeclampsia; trophoblast invasion
期刊名称：ADVANCED SCIENCE （ 影响因子：14.1； 五年影响因子：15.6 ）
ISSN：
年卷期： 2024 年 11 卷 42 期
页码：
收录情况： SCI
摘要： Proper development of the placenta, the transient support organ forms after embryo implantation, is essential for a successful pregnancy. However, the regulation of trophoblast invasion, which is most important during placentation, remains largely unknown. Here, rats, mice, and pigs are used as biomedical models, used scRNA-seq to comparatively elucidate the regulatory mechanism of placental trophoblast invasion, and verified it using a human preeclampsia disease model combined with scStereo-seq. A dual-featured type of immune-featured trophoblast (iTrophoblast) is unexpectedly discovered. Interestingly, iTrophoblast only exists in invasive placentas and regulates trophoblast invasion during placentation. In a normally developing placenta, iTrophoblast gradually transforms from an immature state into a functional mature state as it develops. Whereas in the developmentally abnormal preeclamptic placenta, disordered iTrophoblast transformation leads to the accumulation of immature iTrophoblasts, thereby disrupting trophoblast invasion and ultimately leading to the progression of preeclampsia. Through cross-species comparison, this study reveals the presence of a dual-featured type of immune-featured trophoblast (iTrophoblast) in invasive placentas, which regulates trophoblast invasion during placentation. Immature iTrophoblasts gradually transform into functional maturity with development, and their transformation disorder leads to the accumulation of immature iTrophoblasts, thereby disrupting trophoblast invasion and causing disease progression. image
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