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Whole Genome Sequencing of Hulunbuir Short-Tailed Sheep for Identifying Candidate Genes Related to the Short-Tail Phenotype

文献类型： 外文期刊

作者： Zhi, Dafu 1 ; Da, Lai 3 ; Liu, Moning 1 ; Cheng, Chen 1 ; Zhang, Yukun 2 ; Wang, Xin 1 ; Li, Xiunan 1 ; Tian, Zhipeng 2 ; Ya 1 ;

作者机构： 1.Inner Mongolia Agr Univ, Coll Vet Med, 306 Zhaowuda Rd, Hohhot 010018, Peoples R China

2.Inner Mongolia Agr Univ, Coll Life Sci, Hohhot 010018, Peoples R China

3.Inner Mongolia Acad Agr & Anim Husb Sci, Hohhot 010018, Peoples R China

4.Inner Mongolia Acad Agr & Anim Husb Sci, Hohho

关键词： Hulunbuir short-tailed sheep;short-tail phenotype;whole genome sequencing;selective sweep;T;Brachyury gene;Genome Report

期刊名称：G3-GENES GENOMES GENETICS （ 影响因子：3.154； 五年影响因子：3.369 ）

ISSN： 2160-1836

年卷期： 2018 年 8 卷 2 期

页码：

收录情况： SCI

摘要： The Hulunbuir short-tailed sheep (Ovis aries) is a breed native to China, in which the short-tail phenotype is the result of artificial and natural selection favoring a specific set of genetic mutations. Here, we analyzed the genetic differences between short-tail and normal-tail phenotypes at the genomic level. Selection signals were identified in genome-wide sequences. From 16 sheep, we identified 72,101,346 single nucleotide polymorphisms. Selection signals were detected based on the fixation index and heterozygosity. Seven genomic regions under putative selection were identified, and these regions contained nine genes. Among these genes, T was the strongest candidate as T is related to vertebral development. In T, a nonsynonymous mutation at c.G334T resulted in p.G112W substitution. We inferred that the c.G334T mutation in T leads to functional changes in Brachyuryencoded by this generesulting in the short-tail phenotype. Our findings provide a valuable insight into the development of the short-tail phenotype in sheep and other short-tailed animals.

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