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MicroRNA-497 inhibits thyroid cancer tumor growth and invasion by suppressing BDNF

文献类型： 外文期刊

作者： Wang, Peisong 1 ; Meng, Xianying 1 ; Huang, Yan 2 ; Lv, Zhi 2 ; Liu, Jia 1 ; Wang, Guimin 1 ; Meng, Wei 1 ; Xue, Shuai 1 ; Z 1 ;

作者机构： 1.Jilin Univ, Hosp 1, Dept Thyroid Surg, Changchun 130021, Peoples R China

2.Jilin Univ, China Japan Union Hosp, Dept Orthopaed Surg, Changchun 130033, Peoples R China

3.Jilin Acad Agr Sci, Changchun 130000, Peoples R China

关键词： miR-497;thyroid cancer;BDNF;tumorigenesis;metastasis

期刊名称：ONCOTARGET （ 2016影响因子：5.168； 五年影响因子：5.312 ）

ISSN： 1949-2553

年卷期： 2017 年 8 卷 2 期

页码：

收录情况： SCI

摘要： miR-497 reportedly plays critical roles in tumor development and progression in many types of cancers. We therefore investigated the function and underlying mechanism of miR-497 in thyroid cancer. We found that miR-497 is downregulated in thyroid cancer tissues, and that miR-497 levels are negatively correlated with advanced clinical stage and lymph node metastasis. Overexpressed miR-497 suppressed thyroid cancer cell proliferation, colony formation, migration, and invasion in vitro, and inhibited tumorigenesis in vivo. Moreover, brain-derived neurotrophic factor (BDNF), a known oncogene, was confirmed as a direct target of miR-497 in thyroid cancer cells. miR-497 overexpression suppressed BDNF expression and its downstream pathway(PI3K/AKT) in vitro and in vivo. BDNF levels were upregulated and inversely correlated with miR-497 levels in human thyroid cancer specimens. Rescue experiments showed that forced overexpression of BDNF effectively reversed the tumor suppressive functions of miR-497. These results show that miR-497 is a thyroid cancer tumor suppressor that acts by repressing BDNF.

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