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Hemagglutinating virus of Japan envelope (HVJ-E) can enhance the immune responses of swine immunized with killed PRRSV vaccine

文献类型： 外文期刊

作者： Dai, Zhihong 1 ; Zhang, Quan 3 ; Wang, Zaishi 2 ; Zhang, Zhongqiu 1 ; Guo, Pengju 5 ; Zhao, Deming 1 ;

作者机构： 1.China Agr Univ, Coll Vet Med, State Key Lab Agrobiotechnol, Beijing 100094, Peoples R China

2.China Inst Vet Drug Control, Beijing 100081, Peoples R China

3.Yangzhou Univ, Coll Vet Med, Yangzhou 225009, Peoples R China

4.Minist Agr Peoples Republ China, Vet Bur, Beijing 100125, Peoples R China

5.Guangdong Acad Agr Sci, Inst Vet Med, Guangzhou 510640, Guangdong, Peoples R China

关键词： PRRSV;Vaccines;HVJ-E;Immune responses

期刊名称：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS （ 影响因子：3.575； 五年影响因子：3.381 ）

ISSN： 0006-291X

年卷期： 2011 年 415 卷 1 期

页码：

收录情况： SCI

摘要： Porcine reproductive and respiratory syndrome virus (PRRSV) is an economically detrimental pig pathogen that causes significant losses for the pig industry. The immunostimulatory effects of hemagglutinating virus of Japan envelope (HVJ-E) in cancer therapy and the adjuvant efficacy of HVJ-E have been previously evaluated. The objective of this study was to investigate the adjuvant effects of HVJ-E on immunization with killed PRRSV vaccine, and to evaluate the protective effects of this immunization strategy against virulent PRRSV infection in piglets. Next, the PRRSV-specific antibody response, lymphocyte proliferation, PRRSV-specific IL-2, IL-10 and IFN-gamma production, and the overall protection efficacy were evaluated to assess the immune responses of the piglets. The results showed that the piglets inoculated simultaneously with killed PRRSV vaccine and HVJ-E had a significantly stronger immune response than those inoculated with killed PRRSV vaccine alone. Our results suggest that HVJ-E could be employed as an effective adjuvant to enhance the humoral and cellular responses of piglets to PRRSV. (C) 2011 Elsevier Inc. All rights reserved.

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