广东省农业科学院机构知识库

Effect of genistein on antioxidative defence system and membrane fluidity in chick skeletal muscle cells

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文献类型：外文期刊

作者： Jiang, Z. Y. ¹ ; Jiang, S. Q. ¹ ; Lin, Y. C. ¹ ; Ma, X. Y. ¹ ; Xi, P. B. ¹ ; Cao, T. ¹ ; Wang, X. Q. ¹ ;

作者机构： 1.Guangdong Acad Agr Sci, Inst Anim Sci, Guangdong Publ Lab Anim Breeding & Nutr, Guangzhou 510640, Peoples R China

关键词： genistein;lipid peroxidation;membrane fluidity;antioxidation;chick skeletal muscle cells

期刊名称：ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES （影响因子：2.509；五年影响因子：2.604 ）

ISSN： 1011-2367

年卷期： 2008 年 21 卷 8 期

页码：

收录情况： SCI

摘要： This study was conducted to investigate the protective effect of genistein on the antioxidative defence system and membrane fluidity in chick skeletal muscle cells after supplementation with 0, 20, 40, and 80 mu mol/L genistein in 50 mu mol/L FeSO4/H2O2 treated cells for 24 h. Genistein supplementation recovered the decreased activity of total superoxide dismutase induced by FeSO4/ H2O2, significantly increased glutathione peroxidase activity (p < 0.05) and decreased malondialdehyde production (p < 0.05). The treatment of 80 mu mol genistein in FeSO4/H2O2 treated cells decreased the secretion of creatine kinase (p < 0.05). Fluorescence polarization values and microviscosities observed with FeSO4/H2O2 treated cells were significantly higher than those observed with no FeSO4/H2O2 treated cells. The addition of 80 mu mol/L genistein improved the increased fluorescence polarization value (p < 0.05) caused by FeSO4/H2O2 treatment. The microviscosity value was significantly decreased by adding genistein (p < 0.05). In conclusion, genistein protected skeletal muscle cells from oxidative damage by improving antioxidative status and membrane fluidity.

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