Pathogenesis of nonsuppurative encephalitis caused by highly pathogenic Porcine reproductive and respiratory syndrome virus
文献类型： 外文期刊
作者： Cao, Jianbo 1 ; Li, Bin 1 ; Fang, Liurong 1 ; Chen, Huanchun 1 ; Xiao, Shaobo 1 ;
作者机构： 1.Huazhong Agr Univ, State Key Lab Agr Microbiol, Wuhan 430070, Hubei, Peoples R China
2.Huazhong Agr Univ, Publ Lab Electron Microscopy, Wuhan 430070, Hubei, Peoples R China
3.Huazhong Agr Univ, Lab Anim Virol, Coll Vet Med, Wuhan 430070, Hubei, Peoples R China
4.Jiangsu Acad Agr Sci, Inst Vet Med, Nanjing, Jiangsu, Peoples R China
关键词： Blood-brain barrier;"high fever" disease;highly pathogenic Porcine reproductive and respiratory syndrome virus;nonsuppurative encephalitis
期刊名称：JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION （ 影响因子：1.279； 五年影响因子：1.522 ）
ISSN： 1040-6387
年卷期： 2012 年 24 卷 4 期
页码：
收录情况： SCI
摘要： Since 2006, an unprecedented epidemic of highly pathogenic Porcine reproductive and respiratory syndrome virus (HP-PRRSV) infection has emerged and prevailed in mainland China, causing so called high fever disease with a nervous symptom that is different from typical porcine reproductive and respiratory syndrome. To investigate this syndrome, the brains of pigs inoculated with HP-PRRSV were analyzed. The nucleic acid of HP-PRRSV was detected in brains by reverse transcription polymerase chain reaction. Histological examination demonstrated nonsuppurative encephalitis with lymphohistiocytic perivascular cuffing and infiltration of these leukocytes into the neuropil. Furthermore, transmission electron microscopy revealed that the HP-PRRSV that infected the endothelial cells crossed the blood-brain barrier into the central nervous system then induced cellular damage to neurons and neuroglial cells. These results provide a general insight into the pathway of HP-PRRSV invasion into brain tissue and the pathogenesis of nonsuppurative encephalitis.
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