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The effect of taurine on the toll-like receptors/nuclear factor kappa B (TLRs/NF-kappa B) signaling pathway in Streptococcus uberis-induced mastitis in rats

文献类型： 外文期刊

作者： Miao, Jinfeng 1 ; Zheng, Liuhai 1 ; Zhang, Jinqiu 2 ; Ma, Zili 1 ; Zhu, Wei 1 ; Zou, Sixiang 1 ;

作者机构： 1.Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Peoples R China

2.Jiangsu Acad Agr Sci, Natl Res Ctr Vet Vaccine Engn & Technol China, Nanjing 210014, Peoples R China

关键词： Taurine;Streptococcus uberis;Mastitis;Rat;TLRs/NF-kappa B signaling pathway

期刊名称：INTERNATIONAL IMMUNOPHARMACOLOGY （ 影响因子：4.932； 五年影响因子：4.624 ）

ISSN： 1567-5769

年卷期： 2011 年 11 卷 11 期

页码：

收录情况： SCI

摘要： To investigate whether taurine ameliorates mammary damage in a rat model of S. uberis mastitis by suppressing inflammation related to the toll-like receptors/nuclear factor kappa B (TIRs/NF-kappa B) signaling pathway. Starting on gestation day 14 and continuing until parturition, 100 mg/kg of taurine (group TS) or an equal volume of physiological saline (group CS) was administered daily to rats. Seventy-two hours after parturition, rats were infused with 100 cfu of S. uberis into each of 2 mammary glands. The resultant inflammation, evidenced by swelling, degeneration of secretory epithelium, increased tissue loss and neutrophil (PMN) infiltration was observed. Pretreatment with taurine attenuated inflammatory changes and significantly decreased mRNA expression of TLR-2 (8 h post S. uberis-injection, PI), NF-kappa B p65 (16 h and 24 h PI), and NF-kappa B DNA binding activity (16 h PI). Tumor necrosis factor (TNF)-alpha and inducible nitric oxide synthase (iNOS) levels were also decreased. Significant differences (P < 0.05) were present at 24 h and 48 h PI for TNF-alpha and at 16 h PI for iNOS. TLR-4 mRNA expression was increased by taurine administration and significant differences were observed at 8 h, 16 h and 24 h PI. These results suggest that the in vivo relationship of immunomodulatory reagents with TLRs is complex. Taurine may modulate inflammatory injury induced by S. uberis in mammary glands though TLR-2 and TLR-4. Suppression of inflammation may be related to TLRs/NF-kappa B and may be one mechanism of taurine action in controlling S. uberis mastitis. (C) 2011 Elsevier B.V. All rights reserved.

  • 相关文献

[1]Taurine attenuates Streptococcus uberis-induced mastitis in rats by increasing T regulatory cells. Miao, Jinfeng,Zheng, Liuhai,Yu, Xiaoming,Zhu, Wei,Zou, Sixiang,Zhang, Jinqiu.

[2]The role of NADPH oxidase in taurine attenuation of Streptococcus uberis-induced mastitis in rats. Miao, Jinfeng,Ma, Zili,Zheng, Liuhai,Zhang, Jinqiu. 2013

[3]The role of Ca2+ mediated signaling pathways on the effect of taurine against Streptococcus uberis infection. Dai, Bin,Liu, Ming,Zhang, Yuanshu,Xu, Yuanyuan,Miao, Jinfeng,Zhang, Jinqiu,Lu, Jinye,Yin, Yulong.

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