Characterization of influenza A virus with nine segments: Effect gene segment on virus property
文献类型： 外文期刊
作者： Wu, Rui 1 ; Zhang, Xuke 3 ; Shao, Huabin 1 ; Luo, Qingping 1 ; Yang, Jun 1 ; Xu, Diping 1 ;
作者机构： 1.Hubei Acad Agr Sci, Inst Anim Husb & Vet Sci, Wuhan 430064, Hubei, Peoples R China
2.Hubei Key Lab Anim Embryo Engn & Mol Breeding, Wuhan 430064, Hubei, Peoples R China
3.Luoyang Pulike Bioengn Co Ltd, Natl Res Ctr Vet Med, Luoyang 471003, Henan, Peoples R China
关键词： Influenza virus;H9N2;Nine segments;Virus property
期刊名称：RESEARCH IN VETERINARY SCIENCE （ 影响因子：2.534； 五年影响因子：2.382 ）
ISSN： 0034-5288
年卷期： 2012 年 93 卷 2 期
页码：
收录情况： SCI
摘要： The influenza A virus genome consists of eight segments of negative-strand RNA. In previous study, we generated a recombinant influenza virus with nine segments by reverse genetics. In present study, we evaluated characteristics of the recombinant influenza virus. The recombinant virus exhibited similar property to wild-type virus on virion morphology, virion composition, plaque phenotype and other aspects. Whereas, the recombinant virus propagated to lower titers than did wild-type virus in cells and mice, and there was decreased protein level and vRNA incorporation in the recombinant virions compared to wild-type H9N2 virions. Our results indicated that influenza A virus with eight segments exhibits more advantages than the virus with nine segments. (C) 2012 Published by Elsevier Ltd.
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