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The Toll-like receptor adaptor molecule TRIF enhances DNA vaccination against classical swine fever

文献类型： 外文期刊

作者： Wan, Chao 1 ; Yi, Li 1 ; Yang, Zhenhua 1 ; Yang, Jun 2 ; Shao, Huabin 2 ; Zhang, Chuyu 1 ; Pan, Zishu 1 ;

作者机构： 1.Wuhan Univ, State Key Lab Virol, Coll Life Sci, Wuhan 430072, Peoples R China

2.Hubei Acad Agr Sci, Inst Anim Husb & Vet Sci, Wuhan 430070, Peoples R China

关键词： DNA vaccine;TRIF;Classical swine fever virus (CSFV);E2

期刊名称：VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY （ 影响因子：2.046； 五年影响因子：2.217 ）

ISSN： 0165-2427

年卷期： 2010 年 137 卷 1-2 期

页码：

收录情况： SCI

摘要： To evaluate the effects of the Toll/interleukin-1 receptor domain-containing adaptor-inducing interferon-beta (TRIF) on immune responses induced by DNA vaccines, mice were immunized with the eukaryotic expression plasmid pcDNA/E2 encoding classical swine fever virus (CSFV) E2 alone or in combination with the TRIF genetic adjuvant. Immune responses were examined in immunized mice. Our data demonstrates that co-delivery of the DNA vaccine pcDNA/E2 with the TRIF adjuvant augmented specific humoral and cellular immune responses in a mouse model. Vaccination of pigs confirmed that the pcDNA/E2 in combination with TRIF conferred total protection against lethal challenge with highly virulent CSFV We conclude that TRIF enhances the effects of the DNA vaccine against CSFV infection and could be used as a potential genetic adjuvant for DNA vaccines in large animal species. (C) 2010 Elsevier B.V. All rights reserved.

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[1]Characterization of classical swine fever virus (CSFV) nonstructural protein 3 (NS3) helicase activity and its modulation by CSFV RNA-dependent RNA polymerase. Wen, Guoyuan,Xue, Jinnuo,Shen, Yanping,Zhang, Chuyu,Pan, Zishu,Wen, Guoyuan. 2009

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