Aspergiloid I, an unprecedented spirolactone norditerpenoid from the plant-derived endophytic fungus Aspergillus sp YXf3
文献类型： 外文期刊
作者： Guo, Zhi Kai 1 ; Wang, Rong 2 ; Huang, Wei 3 ; Li, Xiao Nian 4 ; Jiang, Rong 3 ; Tan, Ren Xiang 3 ; Ge, Hui Ming 3 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Peoples R China
2.Hainan Acad Ocean & Fisheries Sci, Haikou 570203, Hainan, Peoples R China
3.Nanjing Univ, Inst Funct Biomol, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Jiangsu, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
关键词： Aspergillus;endophytic fungus;Ginkgo biloba;natural product;norditerpenoid;Trichocomaceae
期刊名称：BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY （ 影响因子：2.883； 五年影响因子：2.785 ）
ISSN： 1860-5397
年卷期： 2014 年 10 卷
页码：
收录情况： SCI
摘要： An unusual C-18 norditerpenoid, aspergiloid I (1), was isolated from the culture broth of Aspergillus sp. YXf3, an endophytic fungus derived from Ginkgo biloba. Its structure was unambiguously established by analysis of HRMS-ESI and spectroscopic data, and the absolute configuration was determined by low-temperature (100 K) single crystal X-ray diffraction with Cu K alpha radiation. This compound is structurally characterized by a new carbon skeleton with an unprecedented 6/5/6 tricyclic ring system bearing an alpha,beta-unsaturated spirolactone moiety in ring B, and represents a new subclass of norditerpenoid, the skeleton of which is named aspergilane. The hypothetical biosynthetic pathway for 1 was also proposed. The cytotoxic, antimicrobial, anti-oxidant and enzyme inhibitory activities of 1 were evaluated.
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