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Aspergiloid I, an unprecedented spirolactone norditerpenoid from the plant-derived endophytic fungus Aspergillus sp YXf3

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文献类型：外文期刊

作者： Guo, Zhi Kai ¹ ; Wang, Rong ² ; Huang, Wei ³ ; Li, Xiao Nian ⁴ ; Jiang, Rong ³ ; Tan, Ren Xiang ³ ; Ge, Hui Ming ³ ;

作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Peoples R China

2.Hainan Acad Ocean & Fisheries Sci, Haikou 570203, Hainan, Peoples R China

3.Nanjing Univ, Inst Funct Biomol, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Jiangsu, Peoples R China

4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China

关键词： Aspergillus;endophytic fungus;Ginkgo biloba;natural product;norditerpenoid;Trichocomaceae

期刊名称：BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY （影响因子：2.883；五年影响因子：2.785 ）

ISSN： 1860-5397

年卷期： 2014 年 10 卷

页码：

收录情况： SCI

摘要： An unusual C-18 norditerpenoid, aspergiloid I (1), was isolated from the culture broth of Aspergillus sp. YXf3, an endophytic fungus derived from Ginkgo biloba. Its structure was unambiguously established by analysis of HRMS-ESI and spectroscopic data, and the absolute configuration was determined by low-temperature (100 K) single crystal X-ray diffraction with Cu K alpha radiation. This compound is structurally characterized by a new carbon skeleton with an unprecedented 6/5/6 tricyclic ring system bearing an alpha,beta-unsaturated spirolactone moiety in ring B, and represents a new subclass of norditerpenoid, the skeleton of which is named aspergilane. The hypothetical biosynthetic pathway for 1 was also proposed. The cytotoxic, antimicrobial, anti-oxidant and enzyme inhibitory activities of 1 were evaluated.

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关键词：

Aspergiloid I, an unprecedented spirolactone norditerpenoid from the plant-derived endophytic fungus Aspergillus sp YXf3

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意见箱

Aspergiloid I, an unprecedented spirolactone norditerpenoid from the plant-derived endophytic fungus Aspergillus sp YXf3

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意 见 箱

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意见箱