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Actinotetraoses A-H: Tetrasaccharide Derivatives from a Grasshopper-Associated Amycolatopsis sp HCa1

文献类型： 外文期刊

作者： Guo, Zhi Kai 1 ; Zhang, Gao Fei 1 ; Jiao, Rui Hua 1 ; Shen, Yan 1 ; Xu, Qiang 1 ; Tan, Ren Xiang 1 ; Ge, Hui Ming 1 ;

作者机构： 1.Nanjing Univ, Inst Funct Biomol, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Jiangsu, Peoples R China

2.Chinese Acad Trop Agr Sci, Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Inst Trop Biosci & Biotechnol, Haikou, Peoples R China

3.Minist Agr, Key Lab Biol & Genet Resources Trop Crops, Haikou, Peoples R China

关键词： Amycolatopsis;Pseudonocardiaceae;insect-derived actinomycete;tetrasaccharide derivatives

期刊名称：PLANTA MEDICA （ 影响因子：3.352； 五年影响因子：3.4 ）

ISSN： 0032-0943

年卷期： 2012 年 78 卷 10 期

页码：

收录情况： SCI

摘要： Chemical investigation of the insect-derived actinomycete Amycolatopsis sp. HCa1 with NMR-guided fractionation led to the isolation of eight new tetrasaccharide derivatives containing an unusual nonreducing glucotetraose skeleton, named actinotetraoses A-H (1-8), and one known compound, tigloside (9). The structures of these compounds were determined on the basis of analyses of their spectroscopic data. The in vitro immunosuppressive activity and cytotoxicity of these compounds were evaluated by T cell viability and MTT assays, respectively. Only actinotetraose E (5) displayed weak immunosuppressive activity.

  • 相关文献

[1]Angucyclines from an insect-derived actinobacterium Amycolatopsis sp HCa1 and their cytotoxic activity. Jiao, Rui Hua,Wang, Ting,Tan, Ren Xiang,Ge, Hui Ming,Guo, Zhi Kai,Liu, Shou Bai. 2012

[2]Actinotetraose L, a new tetrasaccharide derivative isolated from the mycelia of Amycolatopsis sp HCa1. Guo, Zhi-Kai,Yan, Wei,Tan, Ren-Xiang,Ge, Hui-Ming.

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